purpose: to evaluate the results of one 60-degree block conjunctival limbal autograft (clau) surgery in patients with unilateral total limbal stem cell deficiency (lscd). methods: five eyes of 5 patients were included. all patients had a history of chronic total unilateral lscd due to a chemical injury. two patients underwent one 60-degree block clau with amniotic membrane transplantation, two ...

PURPOSE To investigate the effects of loss of osteopontin (OPN) in the healing of the injured cornea in mice. Cell culture study was also conducted to clarify the effects of OPN in fibroblast behaviors. METHODS Ocular fibroblasts from wild-type (WT) and OPN-null (KO) mice were used to study the role of OPN on cell behavior. The effect of the lack of OPN on corneal wound healing was evaluated ...

PURPOSE The involvement of the epithelial mesenchymal transition (EMT) in the process of corneal wound healing remains largely unclear. The purpose of the present study was to gain insight into Slug expression and corneal wound healing. METHODS Slug expression during wound healing in the murine cornea was evaluated using fluorescence staining in vivo. Slug or Snail was stably introduced into ...

Purpose ; Effects of topically applied 0.1% dernmethrsone on epithelirl and endothelial healing following alkali wound were examined. Mehtods ; 30 New Zealand white rabbits were divided in 3 groups. By using a 5.5 mm round filter paper, alkali wounds ( 1N NaOH, 60s ) were produced in one eye of each animal. Group A treated with 0.1% dexamethasone, 3 x/day for 3 weeks. Group B received 0.1% dexa...

Purpose ; Effects of topically applied 0.1% dernmethrsone on epithelirl and endothelial healing following alkali wound were examined. Mehtods ; 30 New Zealand white rabbits were divided in 3 groups. By using a 5.5 mm round filter paper, alkali wounds ( 1N NaOH, 60s ) were produced in one eye of each animal. Group A treated with 0.1% dexamethasone, 3 x/day for 3 weeks. Group B received 0.1% dexa...

Purpose ; Effects of topically applied 0.1% dernmethrsone on epithelirl and endothelial healing following alkali wound were examined. Mehtods ; 30 New Zealand white rabbits were divided in 3 groups. By using a 5.5 mm round filter paper, alkali wounds ( 1N NaOH, 60s ) were produced in one eye of each animal. Group A treated with 0.1% dexamethasone, 3 x/day for 3 weeks. Group B received 0.1% dexa...

Purpose ; Effects of topically applied 0.1% dernmethrsone on epithelirl and endothelial healing following alkali wound were examined. Mehtods ; 30 New Zealand white rabbits were divided in 3 groups. By using a 5.5 mm round filter paper, alkali wounds ( 1N NaOH, 60s ) were produced in one eye of each animal. Group A treated with 0.1% dexamethasone, 3 x/day for 3 weeks. Group B received 0.1% dexa...

There is a significant clinical need to improve current therapeutic approaches to treat ocular surface injuries and disease, which affect hundreds of millions of people annually worldwide. The work presented here demonstrates that the presence of Silk-Derived Protein (SDP) on the healing rabbit corneal surface, administered in an eye drop formulation, corresponds with an enhanced epithelial wou...

PURPOSE To compare the epithelial wound healing response of two preservative-free fluoroquinolones, moxifloxacin and levofloxacin, in patients who underwent cataract surgery. MATERIALS AND METHODS In this prospective, evaluator-masked, randomized clinical trial, 59 eyes of 50 patients who underwent cataract surgery were enrolled. Patients were randomized to receive moxifloxacin 0.5% (n=32 eye...

PURPOSE Heparan sulfate (HS) is a highly modified glycosaminoglycan (GAG) bound to a core protein to form heparan sulfate proteoglycans (HSPGs) that are vital in many cellular processes ranging from development to adult physiology, as well as in disease, through interactions with various protein ligands. This study aimed to elucidate the role of HS in corneal epithelial homeostasis and wound he...