Results from different laboratories indicate that nitric oxide (NO) and carbon monoxide (CO) coexist in the human airways both in health and disease. These gases are present in exhaled human breath and high concentrations of NO as well as CO have been reported in the nasal airways. In addition, exhaled CO and NO are increased in patients with airways inflammation. NO and CO were measured simult...

Airway inflammation is an early feature of asthma. Early detection and anti-inflammatory treatment may have important therapeutic impact. Exhaled nitric oxide is a noninvasive marker of airway inflammation. The current study investigated the association between exhaled nitric oxide and asthma, wheezing phenotypes, atopy and blood eosinophilia in a large group of 4-yr-old children from the gener...

The aim of the study was to investigate whether measurement of nitric oxide in exhaled air could be used for assessing the effects of irritants on the respiratory system, in this case recurrent ozone gassing in an occupational setting. The study population comprised bleachery workers (n=56) from a Swedish pulpmill carrying out ozone-based pulp bleaching since 1992 and controls (n=39). Both grou...

RATIONALE Airway nitric oxide concentrations are reduced in cystic fibrosis (CF). Arginases compete for L-arginine, the substrate of nitric oxide synthesis. OBJECTIVES We hypothesized that increased arginase activity may be one factor contributing to nitric oxide deficiency in CF. MEASUREMENTS We therefore studied sputum arginase activity, exhaled nitric oxide, and pulmonary function in pat...

The aim of this study was to quantify lung oxidative stress in patients with asthma and chronic obstructive pulmonary disease by measuring levels of exhaled carbon monoxide and nitric oxide. Levels of exhaled carbon monoxide, nitric oxide were evaluated in exhaled air of asthma and COPD patients. Moreover, correlation of CO and NO concentrations with degree of airflow obstruction (FEV1% predict...

Letter to the editor re: Mallol J, Riquelme C, Aguirre V, Martinez M, Gallardo A, Sanchez et al. Value of bronchial reversibility salbutamol, exhaled nitric oxide and responsiveness methacholine corroborate diagnosis asthma in children. Allergol Immunopathol (Madr). 2020;48(3):214–22. https://doi. org/10.1016/j.aller.2019.11.001

BACKGROUND Asthma is a heterogeneous disease with variable symptoms especially in children. Exhaled nitric oxide (FeNO) has proved to be a marker of inflammation in the airways and has become a substantial part of clinical management of asthmatic children due to its potential to predict possible exacerbation and adjust the dose of inhalant corticosteroids. OBJECTIVES We analyzed potential fac...