نتایج جستجو برای: experimental autoimmue encephalomyelitis model
تعداد نتایج: 2637440 فیلتر نتایج به سال:
Helmar Waiczies, Stefano Lepore, Jason M Millward, Bettina Purfürst, Thoralf Niendorf, and Sonia Waiczies Ultrahigh Field Imaging in Neuroinflammation, Experimental and Clinical Research Center (ECRC), a cooperation of the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Deutschland, Germany, Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck-Center for...
Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.
Multiple sclerosis involves demyelination and axonal degeneration of the central nervous system. The molecular mechanisms of axonal degeneration are relatively unexplored in both multiple sclerosis and its mouse model, experimental autoimmune encephalomyelitis. We previously reported that targeting the axonal growth inhibitor, Nogo-A, may protect against neurodegeneration in experimental autoim...
experimental allergic encephalomyelitis (eae), a demyelinating disease induced in the animals parallels multiple sclerosis in human in several aspects, provides a useful model to investigate multiple sclerosis. in this study, we have therefore used this model to study functions of nerve growth factor (ngf) in eae. ngf with considerable effects on neuron survival, proliferation and differentiati...
The inverse relationship of multiple sclerosis to sunlight exposure was proposed at least 50 years ago but conclusive evidence is unavailable. Since the proposal made, many researchers have jumped conclusion vitamin D mediates this effect. Vitamin a pro-hormone produced in skin by ultraviolet irradiation and/or sun exposure. In addition, an between plasma levels metabolite, 25(OH)D3, and reduce...
Multiple sclerosis is a chronic, inflammatory, and demyelinating disease of the central nervous system characterized by the pathological infiltration of autoreactive leukocytes. Experimental autoimmune encephalomyelitis serves as a disease model for human multiple sclerosis in mouse and rat (Conlon et al., 1999). Experimental autoimmune encephalomyelitis is induced through sensitization with ne...
An epitope present in the 71-90 sequence of basic protein (BP) has been identified as the dominant epitope recognized by most Lewis rat encephalitogenic T cells isolated during experimental autoimmune encephalomyelitis (EAE). In the present study, we investigated the BP epitopes recognized by Lewis rat T cells in naive rats, in rats suffering from acute EAE, and in recovered rats. T cells isola...
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