Cancer Therapy In article number 2007778, Lin Li, Shao Q. Yao, Wei Huang, and co-workers review the different mitochondria-targeting functional units (Mito-Bomb), various cancer treatment strategies that target mitochondria. picture, commander (scientist or doctor) controls “Mito-Bomb”, which indicates accurate destruction of mitochondria in tumor cells to achieve precise tumors.

Anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet CCl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). Group I (control), while Group II was given CCl4 (3 mL /Kg/day, IP). Animals of Groups III received only propofol (10 mg/Kg/day, IP). Group IV was given propofol+ CCl4. Group V was admin...

Anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet CCl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). Group I (control), while Group II was given CCl4 (3 mL /Kg/day, IP). Animals of Groups III received only propofol (10 mg/Kg/day, IP). Group IV was given propofol+ CCl4. Group V was admin...

This review surveys immunocytochemical and histochemical markers of neuronal lineage for application to tissue sections of fetal and neonatal brain. They determine maturation of individual nerve cells as the tissue progresses to mature architecture. From a developmental perspective, neuronal markers are all about timing. These diverse cellular labels may be classified in two ways: 1) time of on...

BACKGROUND Numerous studies in cultured cells indicate that damage to mitochondrial DNA (mtDNA) dictates cellular responses to oxidant stress, yet the consequences of mtDNA damage have not been studied directly in the preterm lung. OBJECTIVE We sought to determine whether hyperoxia-induced fetal lung dysmorphogenesis is linked to mtDNA damage and establish mtDNA repair as a potential therapeu...

background: the objective of this study was to investigate the effect of vitrification and in vitro maturation on the mitochondrial distribution and atp content of oocytes. methods: the oocytes at germinal vesicle (gv) and metaphase ii (mii) stages were recovered from 6-8 week old nmri strain female mice. the oocytes were divided into vitrified and non-vitrified groups. vitrification was done b...

conclusions the results suggest the important role of the antioxidant system potentiation in the prevention of myocardial damage. results cell degenerative changes, pyknotic nuclei, contraction bands, edema, and loosening of collagen in between muscle fibers were observed during ischemia-reperfusion. myocardial architecture and cellular morphology were recovered in co-administration groups, esp...

introduction: it is well know that fetal distress is one of the important causes of fetus perinatal morbidity and mortality. in this study, we sought to evaluate the association between umbilical coiling index and fetal distress.material and method:this was a case- control study conducted on 90 term pregnant women. study group had fetal distress (abnormal fetal heart rate, meconium staining, ap...

Although the biokinetics, metabolism, and chemical toxicity of atorvastatin calcium are well known, until recently little attention was paid to the potential toxic effects of atorvastatin calcium on re-production and development in mammals. In recent years, it has been shown that atorvastatin calcium is a developmental toxicant when given orally or subcutaneously (SC) to mice. Decreased fertili...