We report the sensitive photoelectrochemical sandwich-type immunosensing of alpha-fetoprotein by using SnO 2 /In S 3 as a novel heterojunction material and horseradish peroxidase (HRP)–CeO an efficient biolabel.

Background Tumor markers have been a valuable tool for decades to aid in the diagnosis, treatment, and monitoring of oncological diseases.
 Objective To retrospectively analyze requisition pattern tumor marker requests at largest tertiary care center eastern Nepal.
 Method A retrospective hospital-based cross-sectional study was conducted obtain data 5 common i.e., Alpha-Fetoprotein (...

Outcome of pregnancies associated with raised serum and normal amniotic fluid a fetoprotein concentrations Open neural tube defects are associated with raised concentrations of a fetoprotein in amniotic fluid and maternal serum. Raised maternal serum a fetoprotein concentrations have also been associated with fetal distress, intrauterine death, threatened abortion, multiple pregnancy, exomphalo...

background: considering the effect of preterm delivery in morbidity and mortality of newborns, its precaution and prevention is so important. objective: to investigate the association between second trimester maternal serum biomarkers (human chorionic gonadotropin, alpha-fetoprotein, non-conjugated estrogen, inhibin a) and pre-term delivery. materials and methods: this is a historical cohort st...

A two year old boy presented with precocious puberty associated with hepatoblastoma. Serum concentrations of beta human chorionic gonadotrophin and alpha-fetoprotein were raised. An aggressive chemotherapeutic regimen resulted in useful palliation and interesting changes in the beta human chorionic gonadotrophin and alpha-fetoprotein concentrations. In contrast to a previous report, the ultrast...

Although the function of alpha fetoprotein (AFP) has never been fully described, quantitative changes in serum levels have been used as a clinical screening tool. Many pathologic conditions, such as hepatocellular or yolk sac tumors and neural tube defects [1]. Although it is rare for a tumor of epithelial origin to produce alpha-fetoprotein, the possibility exists due to the nature of the huma...

Background Chronic hepatitis is an important problem worldwide, associating high morbidity and mortality, and hepatocellular-carcinoma is one of its most severe complications. Multiple studies have tried to identify biomarkers that would allow an earlier detection of hepatocellularcarcinoma (HCC), compared to imagistic exams. Such biomarkers are represented by alpha-fetoprotein (AFP), des-gcarb...

Structural abnormalities Open neural tube defects such as anencephaly and open spina bifida allow cc fetoprotein to escape from cerebral spinal fluid into the amniotic fluid, whence it is absorbed into the maternal blood, producing higher than normal concentrations. This is the basis of a fetoprotein screening performed between 14 and 16 weeks. It is virtually non-invasive, entailing only takin...