Designed Armadillo repeat proteins (ArmRPs) are a novel class of binding proteins intended for general modular peptide binding and have very favorable expression and stability properties. Using a combination of sequence and structural consensus analyses, we generated a 42-amino-acid designed Armadillo repeat module with six randomized positions, having a theoretical diversity of 9.9×10(6) per r...

We have identified four novel repeats and two domains in cell surface proteins encoded by the Methanosarcina acetivorans genome and in some archaeal and bacterial genomes. The repeats correspond to a certain number of amino acid residues present in tandem in a protein sequence and each repeat is characterized by conserved sequence motifs. These correspond to: (a) a 42 amino acid (aa) residue RI...

purpose : to evaluate indications, risk factors and outcome of repeat penetrating keratoplasty (pkp) at a tertiary referral eye care center methods : in this retrospective study, medical chart of patients who underwent repeat pkp at labbafinejad medical center between january 2004 and december 2009 were reviewed. results : a total of 1,859 corneal transplantations were performed on 1,624 eyes d...

Various investigators have identified the major domain organization of LRRK2 (leucine-rich repeat kinase 2), which includes a GTPase ROC (Ras of complex proteins) domain followed by a COR (C-terminal of ROC) domain and a protein kinase domain. In addition, there are four domains composed of structural repeat motifs likely to be involved in regulation and localization of this complex protein. In...

AIM To identify predictors of need for repeat procedures after initial atrial fibrillation (AF) ablation. METHODS We identified a cohort undergoing first time AF ablation at our institution from January 2004 to February 2014 who had cardiac magnetic resonance (CMR) imaging performed prior to ablation. Clinical variables and anatomic characteristics (determined from CMR) were assessed as predi...

BACKGROUND Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS Blood samples were collected from 311 BD-I...

We reportedhere data from a productivity veterinary service that was participatory planned and delivered on farms at the Kanihari Union belongs to Mymensingh District of Bangladesh. We used a set of five forms and a breeding calendar on farm visit once in a month to guide service delivery and acquisition of data and to keep the records on general cattle health, reproduction, udder health and fe...