Some of the mechanical and biological problems surrounding the use of fresh allograft inverted aortic valves as mitral valve substitutes are described. Certain aspects of the problem have been studied expzrimentally. In three sheep 'fresh' aortic valve allografts were-inserted, using cardio-pulmonary bypass, into the main pulmonary artery, and were observed from 5 to 7 months after operation. T...

Results of two-dimensional echocardiographic examinations were compared with angiographic, hemodynamic and surgical results in 44 patients with bioprosthetic valves in mitral and aortic positions who were undergoing elective or urgent reinvestigation 24 to 87 months (mean 34) after implantation. In these patients, there were 18 homograft aortic valves in the aortic position, 9 stent-mounted hom...

BACKGROUND We reviewed the long-term outcomes of aortic root replacement at Asan Medical Center and investigated the predictors affecting mortality. MATERIALS AND METHODS A retrospective analysis was performed on 225 consecutive adult patients undergoing aortic root replacement with mechanical conduits (n=169), porcine aortic root prosthesis (n=23), or aortic homografts (n=33) from January 19...

The successful transplantation of autologous and isologous tissue has been achieved for many years. However, the ability of an adult host animal to reject a homograft from another adult animal of a different strain within the same species has prevented successful homotransplantation in adult animals. As early as 1953 Billingham and Sparrow' demonstrated that living donor epidermal cells treated...

Pseudoaneurysm formation is a rare but potentially life-threatening complication after surgical repair of congenital heart disease. We present a boy with truncus arteriosus communis 14 years after homograft placement in pulmonary position. On follow-up, he presented progressive chronic homograft degeneration. Moreover, a large pseudoaneurysm in the right ventricular outflow tract was surprising...

The immunological response of mice given implants of Ehrlich ascites carcinoma was modified as evidenced by the failure of ascitic mice to reject primary or secondary skin homografts or rat skin heterografts. The site of tumor implantation influenced its effect on the host, since subcutaneously implanted Ehrlich ascites carcinoma did not alter the immune response. The presence of the tumor in t...

Postoperative septicaemia with infective endocarditis is a recognized complication of open-heart surgery, in particular homograft or prosthetic replacement of cardiac valves. Several infective organisms, both bacterial and fungal, have been incriminated but infection due to tubercle bacilli has not, to our knowledge, been reported. The clinicopathological features of this condition are discusse...

Cardiac valvular surgery in patients after lung transplantation is a challenging procedure, reports are scarce. We report 29-year-old patient who underwent concomitant mitral valve reconstruction and implantation of decellularized aortic homograft two years bilateral transplantation.

Homologous vein grafts are becoming increasingly useful in patients without suitable autologous saphenous veins for peripheral arterial bypass procedures [4, 81. However, fresh veins are the only tissue that has been used successfully in homograft vascular reconstruction in terms of long-term patency [4]. The advantages of a reliable method of long-term storage of viable vein segments and the u...