GAMS Development and ARKI Consulting use Quality Assurance (QA) as an integral part of their software development and software publishing process. Research and development in the global optimization area has resulted in promising implementations. Initiated by customer demand, we have been adding three different global codes, BARON, LGO, and OQNLP, to our portfolio of nonlinear optimization solv...

In this paper, a mixed-integer linearized programming (MINLP) model is presented to design a group layout (GL) of a cellular manufacturing system (CMS) in a dynamic environment with considering production planning (PP) decisions. This model incorporates with an extensive coverage of important manufacturing features used in the design of CMSs. There are also some features that make the presented...

The paper presents applications of a class of semi-parametric models called generalized additive models (GAMs) to several business and economic datasets. Applications include analysis of wage-education relationship, brand choice, and number of trips to a doctor’s office. The dependent variable may be continuous, categorical or count. These semiparametric models are flexible and robust extension...

This paper presents a multi-objective mathematical model which aims to optimize and harmonize supply chain reduce costs, improve quality, achieve competitive advantage position using meta-heuristic algorithms. The purpose of optimization in this field is increase quality customer satisfaction production time related prices. present research simultaneously optimized the multi-product multi-perio...

Biolog EcoPlates™ can be used to measure the carbon substrate utilisation patterns of microbial communities. This method results in a community-level physiological profile (CLPP), which yields a very large amount of data that may be difficult to interpret. In this work, we explore a combination of statistical techniques (particularly the use of generalised additive models [GAMs]) to improve the...

PLGA (poly d,l-lactic-co-glycolic acid) nanoparticles (NPs) encapsulating magnetite nanoparticles (MNPs) along with a model drug human serum albumin (HSA) were prepared by double emulsion solvent evaporation method. This Part I will focus on size and size distribution of prepared NPs, whereas encapsulation efficiency will be discussed in Part II. It was found that mean hydrodynamic particle siz...

Positive allosteric modulators of GABAA receptors (GAMs) acting at specific subtypes of GABAA receptors effectively restore compromised spinal pain control in rodents. Studies addressing a similar antihyperalgesic effect in humans are sparse and are hampered by sedative effects of nonselective GAMs available for use in humans. We present results from a randomized controlled double-blind crossov...

The absolute rate of nonlinear energy transfer among broadband turbulence, low-frequency zonal flows (ZFs) and geodesic acoustic modes (GAMs) was measured for the first time in fusion-grade plasmas using two independent methods across a range of heating powers. The results show that turbulent kinetic energy from intermediate frequencies (20-80 kHz) was transferred into ZFs and GAMs, as well as ...

The extent to which geochemical variation shapes the distribution of phototrophic metabolisms was modeled based on 439 observations in geothermal springs in Yellowstone National Park (YNP), Wyoming. Generalized additive models (GAMs) were developed to predict the distribution of phototrophic metabolism as a function of spring temperature, pH, and total sulfide. GAMs comprised of temperature exp...