N Engl J Med 2004;351:675-82. Copyright © 2004 Massachusetts Medical Society. During a routine visit, a 59-year-old woman, who describes herself as a lifetime “worrier” and has a family history of depression, reports having restless sleep, muscle tension, and fatigue. Recently, her anxiety has intensified about her children, her job, and her health, and it is having a negative effect on her fam...