The association between actinic granuloma and giant cell arteritis (temporal arteritis) has been claimed by some authors. There is a hypothesis that actinic radiation has the principal role in the etiology of both diseases in a similar way. Here, we report a case of actinic granuloma that had characteristic pathologic features of giant cell arteritis in histopathologic examination without clini...

Osteoclast-like giant cell tumor of the pancreas is a rare non-endocrine neoplasm composed of reactive multinucleated giant cells admixed with mononuclear stromal cells. We report a case of osteoclast-like giant cell tumor of the pancreas in a 58-year-old female with vague clinical symptoms. Endoscopic ultrasound-guided aspirate from the mass revealed numerous characteristic osteoclast-like gia...

purpose: to present a case of orbital granular cell tumor, a rare orbital tumor. case report: a 55-year-old woman presented with binocular diplopia and right ocular displacement. the problem had initiated 3 years ago. a firm nontender mass at the region of the right lower lid was visible. orbital ct-scan disclosed a well-defined mass in the inferior right orbit with involvement of the inferior ...

Objective(s):miR-125b has been identified as a tumor suppressor in many tumors, but its role in giant cell tumor (GCT) of bone remains poorly understood. The current study aimed to investigate the potential role and mechanism of miR-125b in GCT. Materials and Methods:Expression levels of miR-125b in GCT tissues were determined using RT-PCR. The cell proliferation was surveyed by direct cell coun...

CONTEXT The combination of an osteoclastic giant cell tumor and a pleomorphic giant cell carcinoma of the pancreas is distinctly unusual and is associated with an adverse outcome. The origin of these two components within a tumor has long been debated based on the immunohistochemical and ultra-structural analysis. CASE REPORT Herein we describe a tumor with amalgamation of these two distinct ...

Giant cell tumor of soft tissue is a rare tumor first described by Salm and Sissons in 1972 as being a distinct entity.(1) Histologically, it is composed of multinucleated giant cells dispersed among mononuclear cells, and is indistinguishable from its bone equivalent.(2) The majority of these tumors have been reported to occur in the lower extremity.(2,3) We describe a case of giant cell tumor...

Case Description and Clinical Findings- A seven-year-old male German shepherd dog was referred to Small Animal Clinic with severe lameness (non-weight-bearing) and considerable localized proximal right humerus swelling. Radiographic study revealed severe soft tissue swelling and pathologic fracture of proximal right humerus. Immediately, the right forelimb was removed surgically and once sample...