Glutamate-mediated excitotoxicity and neurodegeneration have been shown as pathophysiological hallmarks of multiple sclerosis (MS) and other autoimmune inflammatory CNS disorders. N‑Methyl‑D‑Aspartate (NMDA) receptors play a pivotal role in the mediation of neuronal glutamate excitotoxicity leading to cellular damage and apoptotic cell death. Current treatment approaches targeting glutamate exc...

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian central nervous system that has significant beneficial effect on human health. Traditional microbial GABA synthesis requires continuous oxygen supplementation. Here, new anaerobic platform for production was established with engineered C. tyrobutyricum ATCC 25755, which considered an ideal microbial-cell fact...

Fast excitatory synaptic transmission in the mammalian central nervous system is mediated by glutamate-activated α-amino-5-methyl-3-hydroxy-4-isoxazole propionate (AMPA) receptors. Glutamate binding to AMPA receptors leads rapid activation and desensitization. Synaptically released Zn2+ works as a neuromodulator many brain regions. Here, we show that inhibits GluA2(Q) homomeric an activity- vol...

This article refers to:A Co(II) coordination polymer: enhanced fentanyl analgesic activity via reducing glutamate receptor expression

Objective(s): K+ channel blocker 4-aminopyridine (4-AP) stimulates the release of glutamate from nerve terminals and induces seizures. Berberine as a potential herbal drug exerts several pharmacological actions on the central nervous system including anxiolytic, anticonvulsant, and neuroprotective properties. The present study aimed to investigate the effect of berberine on seizure onset and ti...

Introduction We evaluated whether 12-week intake of molecular hydrogen (H2) in 5 overweight adults (3 women; age: 50.2 ±11.9 years, body mass index: 29.4 ±2.1 kg/m2) affects brain levels the glutamate-glutamine-GABA cycle, critical amino acid neurotransmitters mechanism neuronal activation during appetite regulation. Material and methods A 1.5-T single-voxel proton magnetic resonance spectrosco...

background: the areas of the bed nucleus of the stria terminalis (bst) with a high density of estrogen receptors are involved in cardiovascular regulation and send axonal projections to the rostroventrolateral medulla (rvlm). we aimed to find the contribution of the rvlm to cardiovascular responses elicited by glutamate microinjection into the bst. methods: experiments were done in α-chloralose...

Both glutamate receptors and transporters are known to be important in the postsynaptic regulation of glutamate neurotransmission. However, the maturation profile of glutamate transporter EAAC1 and glutamate receptor subunits (NR1, NR2A and NR2B; and GluR 1-4) in functionally activated saccule-related vestibular nuclear neurons of postnatal rats remains unclear. In the present study, conscious ...

Both glutamate receptors and transporters are known to be important in the postsynaptic regulation of glutamate neurotransmission. However, the maturation profile of glutamate transporter EAAC1 and glutamate receptor subunits (NR1, NR2A and NR2B; and GluR 1-4) in functionally activated saccule-related vestibular nuclear neurons of postnatal rats remains unclear. In the present study, conscious ...

Ethnopharmacological relevance: Ocimum basilicum L. (Lamiaceae) is a medicinal plant known in Cameroon for the treatment of many ailments like anxiolytic, antispasmodic and mental disorders. Aim study: The aim this study to evaluate neuroprotective effects basilicum. Materials methods: T-maze test open field assay oxidative stress parameters were used detecting its capacity protect neurons agai...