Polyproline is a material of great interest in biomedicine due to its helical scaffold structural importance collagen and mucins ability gel change conformations response temperature. Appending function-modulating chemical groups such desirable diversify potential applications. Here, we describe the synthesis high-molecular-weight homo, block, statistical polymers azide-functionalized proline. ...

In this work, three surface functionalization processes have been studied: the spontaneous grafting fromdiazonium salts, the chemically induced grafting from diazonium salts and the chemically induced graftingfrom diazonium salts in presence of vinylic monomers (which is Graftfast). These processes work at roomtemperature, atmospheric pressure, in aqueous medium and without any ext...

On the scaffold: Grafting protein epitopes onto conformationally designed scaffolds represents a very promising approach to protein ligand design, with potential applications in many areas of chemical biology and molecular medicine. The highlighted article describes the design and anticancer activity of novel p53/MDM2 inhibitors built upon a scorpion toxin scaffold. Other approaches to protein ...