Concentration-response curves (CRCs) are characterized by a midpoint (EC50) and high-concentration asymptote (POmax) that relate to the agonist's affinity efficacy. Recently, third agonist attribute, efficiency, was defined as fraction of ligand binding energy is applied conformational change activates receptor. We show efficiency can be calculated from EC50 POmax estimate its value for 17 agon...

worldwide networks of seismic recording instruments mostly record only translational ground motion in two or three orthogonal directions. rotational component of earthquake is not commonly recorded. several theories are available to estimate a torsional component from recorded translational components of ground motion. in this paper detailed investigations are made to study the relative perform...

the present study was conducted in the rangeland of glandrood watershed in the province of mazandaran. the objective of this study was to compare between the ecological amplitude of festuca ovina l., and poa bulbosa l., using the function hof along the gradient of the environmental variables. for this purpose 150 plots of 1m2 were established along the altitude gradient. the sampling method was...

Why is maximal running speed reduced on curved paths? The leading explanation proposes that an increase in lateral ground reaction force necessitates a decrease in peak vertical ground reaction force, assuming that maximum leg extension force is the limiting factor. Yet, no studies have directly measured these forces or tested this critical assumption. We measured maximum sprint velocities and ...

We put forward a constructive definition of electricity forward price curve with crosssectional timescale encompassing hourly frequency upward. The curve is jointly consistent to both riskneutral market information, as represented by baseload and peakload futures quotes, and historical market information, as mirrored by periodical patterns exhibited by time series of dayahead prices. On a metho...

Fracture regime of asphalt concrete is utmost importance in the sustainable design optimized mixtures against low-temperature cracking. The energy dissipated blunting crack tip, stable growth, as well post-peak resistance to propagating comprise overall fracture performance mixtures. In this research, employing curve (R-curve) concept, three parameters: cohesive energy, and rate, are extracted ...