نتایج جستجو برای: heart injury
تعداد نتایج: 689224 فیلتر نتایج به سال:
On the evening of October 8th, 1877, I vras called to see a coolie who had been crushed between two buffers while shunting carriages at the Amritsar Railway station. I arrived on the epot a few minutes after the accident had occurred, and found the man dead, and was informed by the bystanders that death had been instantaneous. Apparently there was nothing to account for such a calamity ; the fa...
Abstract Introduction: Resent studies have been shown beneficial effects of hyperoxia pretreatment against ischemia-reperfusion injury in different organs. The aim of the present study was to investigate early and late effects of normobaric hyperoxia (≥95% O2) pretreatment on ischemia-reperfusion injuries in isolated rat hearts. Methods: Following 60 and 180 minutes of hyperoxia, rat hearts w...
Background—Ischemic heart disease is the greatest cause of death in Western countries. The deleterious effects of cardiac ischemia are ameliorated by ischemic preconditioning (IPC), in which transient ischemia protects against subsequent severe ischemia/reperfusion injury. IPC activates multiple signaling pathways, including the reperfusion injury salvage kinase pathway (mainly PI3K-Akt-glycoge...
The article describes a clinical case of the COVID-19 viral infection complicated with severe pneumonia, “cytokine storm”, bacteriemia, and acute myocardial injury decompensated chronic heart failure, ventricular arrhythmias, formation an intracardiac thrombus in elderly patient underlying clinically significant cardiovascular pathology.
Ischemia reperfusion (I/R) injury which inevitably occurs during heart transplantation is the major factor leading to organ failure and graft rejection. In order to develop new therapies to prevent I/R injury, we used both a murine heart transplantation model with 24 hour cold I/R and an in vitro cell culture system to determine whether growth differentiation factor 15 (GDF15) is a protective f...
The relations between ATP depletion, increased cytosolic free calcium concentration ([Ca;]), contracture development, and lethal myocardial ischemic injury, as evaluated by enzyme release, were examined using 19F nuclear magnetic resonance to measure [CaiJ in 1,2-bis(2amino-5-fluorophenoxy)ethane-N,N,N',N'-tetraacetic acid (5F-BAPTA)-loaded perfused rat hearts. Total ischemia at 370 C was induc...
Heart transplantation (HTx) is the ultimate treatment for end-stage heart failure. The number of patients on waiting lists for heart transplants, however, is much higher than the number of available organs. The shortage of donor hearts is a serious concern since the population affected by heart failure is constantly increasing. Furthermore, the long-term success of HTx poses some challenges des...
A consensus conference on cardio-renal syndromes (CRS) was held in Venice Italy, in September 2008 under the auspices of the Acute Dialysis Quality Initiative (ADQI). The following topics were matter of discussion after a systematic literature review and the appraisal of the best available evidence: definition/classification system; epidemiology; diagnostic criteria and biomarkers; prevention/p...
Unlike zebrafish and newt hearts, mammalian hearts have limited capacity to regenerate. Upon injury or disease, the adult mammalian hearts form a fibrotic scar. Recently, it was shown that neonatal mouse hearts can regenerate similarly to adult zebrafish hearts. However, this capacity quickly decreases after postnatal day 7 (P7). Understanding the molecular mechanisms underlying neonatal heart ...
Summary Interleukin (IL)-33 is highly expressed in the nucleus of cells present at barrier sites and signals via ST2 receptor. IL-33 signalling essential for return to tissue homeostasis after acute inflammation, promoting fibrinogenesis wound healing injury sites. However, this wound-healing response becomes aberrant during chronic or sustained leading transforming growth factor beta (TGF-β) r...
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