WEBSTER, WILLIAM P., CHARLES F. ZUKOSKI, PETER HUTCHIN, ROBERT L. REDDICK, STANLEY R. MANDEL, AND GEORGE D. PENICK. Plasma factor VIII synthesis and control as revealed by canine organ transplantation. Am. J. Physiol. 220(5) : 1147-1154. 1971.The synthesis and control of factor VIII (antihemophilic factor, AHF) have been studied by transplanting livers, spleens, and kidneys into hemophilic and ...

Hemophilic bleeding into joints causes synovial and microvascular proliferation and inflammation (hemophilic synovitis) that contribute to end-stage joint degeneration (hemophilic arthropathy), the major morbidity of hemophilia. New therapies are needed for joint deterioration that progresses despite standard intravenous (IV) clotting factor replacement. To test whether factor IX within the joi...

Hemophilia is a genetic disease caused by a deficiency of blood coagulation factor VIII or IX. Bleeding into joints is the most frequent manifestation of hemophilia. Hemarthrosis results in an inflammatory and proliferative disorder termed hemophilic synovitis (HS). In time, a debilitating, crippling arthritis, hemophilic arthropathy, develops. Although the clinical sequence of events from join...

have indicated that normal cell-free human plasma contains some factors which are deficient in hemophilia. There is evidence that by the parenteral administration of derivatives of normal cell-free plasma in hemophilia, the coagulation defect can be modified toward normal. The present communication reviews some of the older work on this subject and presents new evidence accumulated during the p...

Up to 30% of haemophilia A patients and up to 3% of haemophilia B patients develop neutralizing antibodies (inhibitors) to factor VIII or factor IX, rendering replacement therapies ineffective and making the management of bleeding episodes particularly challenging.1–3While patients with low titre inhibitors may benefit from higher doses of factors VIII or IX, patients with higher antibody level...

background: treating a chronic disease such as hemophilia is to improve the symptoms and quality of life (qol) of the patients. this study aimed to study the quality of life among hemophilic children and compare the quality of life between patients receiving prophylactic or on demand treatments. materials and methods: in this descriptive-comparative study, we enrolled 60 patients from three mai...

By utilizing a simple modification of previous immunological assays, we have demonstrated that most, if not all, hemophilic plasmas contain antigen reactive with human antibodies directed against Factor VIII procoagulant activity (VIIIc). Antibodies developing in a nonhemophiliac patient and in a hemophiliac patient gave similar results. The VIIIc antigen so identified was removed from hemophil...