the anti-cancer activity of metal ions in the lanthanide group is being considered recently. it has been reported that cerium salts might stimulate the metabolism and therefore, produce anti-cancer effects. however, little is known about the effects of protein-cerium complex in controlling cancer cell growth. the aim of the present study was to elucidate the possible pathways for the cytotoxic ...

Adenovirus causes a number of diseases in Human, and to date, no specific antiviral therapy approved against this virus. Thus, searching for effective anti-adenovirus agents seems to be required. Many studies showed that components derived from medicinal plants had effective antiviral activity. Therefore, the present was aimed to evaluate activity of Melissa officinalis L. extract against adeno...

abstract background and aims: to identify and isolation of viruses a susceptible cell is need which can be primary or line. the use of primary cells is laborious, time consuming and expensive, while the use of cell lines is much easier and faster. irkhbk cell line was originated from primary cells of bovine kidney by continuous passage. the aim of this study was to introduce the irkhbk cell lin...

objective: the study of physiological changes in recombinant cell lines provides useful information to improve production performance. in this study, we investigate the effects of an anti-cd33 chimeric igg4 expression on sp2.0 cell growth. methods: variable region genes of light and heavy chains of monoclonal antibody produced by m195 were cloned in pfuse-clig-hk and pfuse-chig-hg4 expression ...

background: both azadirachtin and rotenone, two botanical pesticides have shown inhibit the growth of cultured insect cells. the inhibitory effect of rotenone on cell growth is through disruption of electron transport chain, but exact mechanism of effect of azadirachtin on growth of cell is unknown. this study was carried out to compare the effect of these phytochemical on oxygen consumption by...

One new phenylpropanoid, turformosin A (1), and one new triterpene, turformosinic acid (2), together with 16 known compounds, were isolated from the stems of Turpinia formosana Nakai. All structures were elucidated on the basis of spectroscopic analysis, including 1D- and 2D-NMR techniques and MS analysis. Selected isolated compounds were evaluated for in vitro cytotoxicity against four human c...

Aziridine-containing compounds have been of interest as anticancer agents since late 1970s. The design, synthesis and study of triaziquone (TZQ) analogues with the aim of obtaining compounds with enhanced efficacy and reduced toxicity are an ongoing research effort in our group. A series of bis-type TZQ derivatives has been prepared and their cytotoxic activities were investigated. The cytotoxi...

mycoplasma and ureaplasma species are the most serious contaminants of cell cultures and this remains one of the major problem encountered in biological research using cell cultures. the aim of this study was to investigate the rate of mycoplasma and a total of 100 different cell culture specimens including, r228, hela, vero, mdck, l20, rd and hep2 were collected. then the specimens were invest...

background: most cancer cells become resistant to anti-cancer agents. in the last few years, a new approach for targeted therapy of human cancer has been developed using immunotoxins which comprise both the cell targeting and the cell killing moieties. methods: in the present study, the recombinant shiga toxin a1 subunit fused to human granulocyte-macrophage colony stimulating factor (a1-gm-csf...