OBJECTIVE A liver biopsy is the 'reference standard' for diagnosing and staging liver fibrosis but with many disadvantages. Therefore, developing a non-invasive index for predicting fibrosis is very valuable. We developed and validated a novel non-invasive index for predicting significant fibrosis in patients with chronic hepatitis B infection. DESIGN A retrospective cohort study. SETTING C...

BACKGROUND The aim of this study was to evaluate oxidative stress in various clinical forms of hepatitis B infection and to investigate its role in the development of the chronic form of the disease. METHODS Ninety-three patients with inactive hepatitis B surface antigen (HbsAg) carrier state (IHBCS), 65 patients with chronic hepatitis B infection (CHB), and 42 healthy adults were included in...

Hepatitis C virus is associated with several immune-mediated phenomena, presented usually as extra-hepatic hepatitis C manifestations. A predisposition to autoimmunity associated with the presence of baseline autoantibodies has been demonstrated in interferon mediated autoimmune diseases. We report a male patient, 34 years old, with genotype 1, chronic hepatitis C (hepatitis C viremia 1.432.463...

BACKGROUND AND STUDY AIMS Increased alanine aminotransferase (ALT) levels with negative hepatitis B virus (HBV) DNA by hybridization is a common problem in Turkey where is a mild endemic region. We aimed to evaluate the causes of elevated ALT levels in patients who are negative for hepatitis B e antigen (HBeAg) and HBV DNA (by hybridization) for at least 6 months. PATIENTS-METHODS Forty-nine ...

Sir, I have read the excellent paper by Shifflet and Wu.1 Watanabe et al reported that several metabolic disturbances, such as obesity, insulin resistance, and hepatic steatosis, are significant risk factors for decreased sustained virologic response to interferon and ribavirin combination antiviral therapy in chronic hepatitis C patients.2 It should be noted, for completeness, the influence of...

OBJECTIVES To validate the diagnostic performance of Hepa-Index in predicting different stages of hepatic fibrosis in Egyptian patients with chronic hepatitis C (CHC). Methods: Hundred treatment naïve chronic hepatitis C Egyptian patients were prospectively enrolled between June 2014 and January 2015. They were subjected to: platelet count, alpha-2-macroglobulin (α2-MG), total bilirubin, gamma ...

Autoimmune hepatitis (AIH) is a rare cause of chronic liver disease (CLD). It presents with varied clinical features from acute hepatitis to CLDs like chronic viral hepatitis and alcoholic liver disease, making it difficult to diagnose in the absence of a high index of suspicion and adequate laboratory support. Autoantibody-mediated hepatocyte injury is the major feature of AIH. We present a 44...

introduction: complications of obesity and high fat in children are grave now and future. the aim of this research is comparing percentage of body fat in active and inactive girls using anthropometric parameters.materials and methods: this research is descriptive- correlation that 144 active(n= 70) and inactive(n= 74) girls aged 8 to 10 years old were selected by random cluster sampling method ...

the present research designed to evaluate the effects of foliar application of methyl jasmonate (meja), salicylic acid (sa) and potassium sulfate on improving fruit quality and photosynthesis system. ten treatments include: sa (0.3, 0.6 and 0.9 mm), meja (0.5, 1 and 2 mm), potassium sulfate (0.5, 1 and 1.5%) and distilled water (control) were sprayed on pomegranate trees 2 and 7 weeks after ful...

Abstract Successful clinical drug development requires rational design of combination treatments based on preclinical data. Anti-hepatitis C virus (HCV) drugs exhibit significant diversity in antiviral effect. Dose-response assessments can be used to determine parameters profiling the diverse effect during treatment. In current study, a combined experimental and mathematical approaches were com...