The researchers aimed to evaluate the effects of long non-coding ribonucleic acid plasmacytoma variant translocation 1 (lncRNA PVT1) regulating octamer binding transcription factor 4 (OCT4) expression on hepatocellular carcinoma (HCC) cells. It was discovered that in contrast blank group, si-PVT1 group had lower PVT1 and OCT4 expressions, number invading cells wound healing rate, higher radiose...

Hepatocellular carcinoma (HCC) poses a significant global health concern, with its incidence steadily increasing. The development of HCC is multifaceted, multi-step process involving alterations in various signaling cascades. In recent years, progress has been made understanding the molecular pathways that play central roles hepatocarcinogenesis. particular, EGFR/PI3K/AKT/mTOR pathway garnered ...

Hepatocellular carcinoma (HCC) is one of the common major malignancies worldwide and has third highest mortality rate any malignancy. The current field treatment for hepatocellular multidisciplinary in involvement a combination therapeutic approaches, among which immunotherapy modality advanced carcinoma. This review provides new ideas developing regimens improving efficacy patients with liver ...

A 10-year-old spayed female Pomeranian dog was referred for hepatic mass evaluation. Blood tests revealed mildly elevated alkaline phosphatase activities. Computed tomography a with multiple nodules on the right medial lobe adjacent to caudal vena cava; histopathology confirmed mixed hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). Because of incomplete resection, adjuvant thera...

Oxaliplatin (OXA) resistance limits the efficiency of treatment for hepatocellular carcinoma (HCC). Studies have shown that PDZ-binding kinase (PBK) plays important roles in tumors. However, role PBK HCC is still a problem. In this study, we explored whether involved chemoresistance to OXA HCC. Expressions six cell lines and one human hepatocytes line were determined by real-time quantitative P...

Abstract Background Accumulating evidences have been reported that long noncoding RNAs play crucial roles in the progression of hepatocellular carcinoma (HCC). SnoRNA host gene 6 (SNHG6) is believed to be involved several human cancers, but specific molecular mechanism SNHG6 HCC not well studied. Methods In this study, we experimentally down-regulated two cell lines vitro , and then measured pr...

CircRNAs are crucial in tumorigenesis and metastasis, comprehensively downregulated hepatocellular carcinoma (HCC). Previous studies demonstrated that the back-splicing of circRNAs was closely related to 3′-end splicing. As a core executor cleavage, we hypothesized CPSF3 modulated circRNA circularization. Clinical data were analyzed establish prognostic correlations. Cytological experiments per...

Hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI) have worse survival. Whether the presence of MVI indicates necessity more aggressive locoregional treatments for rec...