The study investigated whether a persistent impairment of insulin secretion resulting from mild protein restriction predisposes to loss of glucoregulatory control and impaired insulin action after the subsequent imposition of the diabetogenic challenge of high-fat feeding. Offspring of dams provided with either control (20% protein) diet (C) or an isocaloric restricted (8%) protein diet (PR) we...

According to the European statistics, approximately 26 million patients worldwide suffer from heart failure (HF), and this number seems be steadily increasing. Inflammation plays a central role in development of HF, pro-inflammatory cytokine Tumor necrosis factor-? (TNF-?) represents inflammation gold-standard biomarker. Early detection crucial for prognosis treatment HF. An Ion Sensitive Field...

BACKGROUND Myofilament Ca(2+) sensitizers enhance contractility but can adversely alter diastolic function through sensitization to low intracellular Ca(2+) concentration. Concomitant phosphodiesterase III inhibition (PDE3I) may offset diastolic changes but limit the mechanoenergetic benefits. We tested whether selective Ca(2+) sensitization in vivo with the use of EMD-57033 enhances both systo...

OBJECTIVES To compare the diet quality and weight status of girls consuming diets meeting the recommendation of the American Academy of Pediatrics for dietary fat with those of girls consuming >30% of energy from fat and to examine relationships between girls' dietary fat intake, mothers' nutrient intakes, and mothers' child-feeding practices. DESIGN Participants were 192 white girls and thei...

We report on a detailed characterization of complex dielectric response of Na-DNA aqueous solutions by means of low-frequency dielectric spectroscopy (40 Hz-110 MHz). Results reveal two broad relaxation modes of strength 20<Deltaepsilon(LF)<100 and 5<Deltaepsilon(HF)<20, centered at 0.5 kHz<nu(LF)<70 kHz and 0.1 MHz<nu(HF)<15 MHz. The characteristic length scale of the low-frequency (LF) proces...

The effect of dietary intake of flavonols (predominantly quercetin) on oxidative DNA damage was studied in thirty-six healthy human subjects (sixteen men, twenty women). The study was a randomised crossover study, comprising two 14 d treatments of either a low-flavonol (LF) or high-flavonol (HF) diet with a 14 d wash-out period between treatments. Subjects were asked to avoid foods containing f...

Background—Tumor necrosis factor(TNF ), an inflammatory cytokine, was reported to be elevated in trials of heart failure (HF) with reduced ejection fraction (EF) and associated with mortality. Whether this is true for HF with preserved EF is unknown, and community data are lacking. We evaluated the distribution of TNF , its association with baseline characteristics and mortality, and its benefi...