The aim of the present work was to develop a gastroretentive floating tablet of Atenolol and investigate the effects of both hydrophilic and hydrophobic retardant on in vitro release. Atenolol is an antihypertensive drug with an oral bioavailability of only 50% because of its poor absorption from lower gastrointestinal tract. The floating tablets of Atenolol were prepared to increase the gastri...

The clinical application of sirolimus (SRL) as an immunosuppressive agent is largely hampered by its narrow therapeutic range. This study focused on developing SRL tablets with a sustained release profile for better safety. SRL was highly water insoluble and its solubility has been efficiently enhanced by preparing self-microemulsifying drug delivery system (SMEDDS). The SRL-SMEDDS was physical...

The clinical application of sirolimus (SRL) as an immunosuppressive agent is largely hampered by its narrow therapeutic range. This study focused on developing SRL tablets with a sustained release profile for better safety. SRL was highly water insoluble and its solubility has been efficiently enhanced by preparing self-microemulsifying drug delivery system (SMEDDS). The SRL-SMEDDS was physical...

This investigation describes the preparation and in vitro evaluation of gastro retentive floating tablets of atorvastatin calcium. Two hydrophilic cellulose derivatives, Methocel K4M and Methocel K15M CR were used in floating tablets as gel forming agents to control drug release. Sodium bicarbonate and citric acid were incorporated as gas generating agents. The tablets prepared by direct compre...

Introduction: This study is to formulate the Euterpe Oleracea in-situ gel for better treatment of conjunctivitis. The ophthalmic drug solution can treat ocular infections effectively. Aim: Formulation and evaluation Eutepe conjunctivitis Methodology: containing prepared by using different polymers like carbopol-940, HPMC K15, K100, K4M, as a pH triggered gelling system, these are used controlle...

INTRODUCTION Imatinib mesylate is an antineoplastic agent which has high absorption in the upper part of the gastrointestinal tract (GIT). Conventional imatinib mesylate (Gleevec) tablets produce rapid and relatively high peak blood levels and requires frequent administration to keep the plasma drug level at an effective range. This might cause side effects, reduced effectiveness and poor thera...

Cilnidipine, a novel calcium antagonist accompanied with Ltype and N-type calcium channel blocking function, is mainly used for treatment of hypertension. Due to its N-type calcium channel blocking properties, it has more advantages compared to conventional calcium channel blockers. The present investigation is aimed to formulate a pulsatile drug delivery system with a lag time of about 6 hr. C...

The study on the effect of polymer concentration in vitro drug release profile revealed that there is a change parameters (t50, t80, and MDT) with concentration. Fraction HPMC K4M, K 100 M, Ethyl Cellulose were required to be 15, 10, 7 mg respectively for designing optimized batch F7. rate Colchicine decreased proportionally an increase ethyl K100 M. Also high amount K4M leads less initial sust...

161 Abstract: Pulsatile systems are best for the drugs, which follows chronopharmacological behaviour where night time dosing is required, drugs having high first-pass effect and having specific site of absorption in GIT. In this study, colon targeted pulsatile release tablets of atenolol was prepared using press coating technique to treat hypertension in the early hours of the morning. Pulsati...