Alleles of major histocompatibility complex (MHC) loci are associated with certain types of diseases, including those of infectious and autoimmune origin. MHC products can promote susceptibility or resistance to disease by stimulating or inhibiting immune responses. Recent evidence suggests that MHC-associated peptides derived from self-proteins can act as antagonists of T-cell activation, ther...

Paediatricians have long been deeply concerned with problems of infection. The sharp decrease in childhood mortality in recent decades in highly developed countries is mainly due to progress in preventing and treating infection: for example, in Switzerland in 1973 there were about 88 000 births and only 16 deaths due to infection in children aged between 2 and 4 years in contrast to 76 killed b...

background: major histocompatibility complex (mhc) plays a central role in regulation and control of the immune responses to infectious diseases. due to its polymorphism, individual differences in response to vaccines have been observed in different chicken populations. studying the association of chicken mhc with immune response to vaccines will help the control of infectious disease and vacci...

Vitiligo is an autoimmune skin disease which is characterized by depigmented patches due to loss of pigment cells. Evidence suggests that cell-mediated immunity plays a role in melanocyte destruction while some patients have antibodies to melanocytes or melanocytic proteins. Vitiligo is strongly associated with a number of autoimmune disorders. Autoimmune thyroiditis is the most prevalent disea...

J.t is well established thait both the an ti body de­ficiency and the reaction beru,een antigen and _ant.i­ hody cause many diseases Then there is antibody ·c1e­,ficiency the resulting disease is called antibody defi­ciency disease; and when the contact of antigen vih antibody produces the disease or the complex of anti­gen with antibody precipitates and causes tissue dama­ge the ,lesion is cal...

Cigarette smoking is associated with numerous diseases and poses a serious challenge to the current healthcare system worldwide. Smoking impacts both innate and adaptive immunity and plays dual roles in regulating immunity by either exacerbation of pathogenic immune responses or attenuation of defensive immunity. Adaptive immune cells affected by smoking mainly include T helper cells (Th1/Th2/T...

HLA-C, a gene located within the major histocompatibility complex, has emerged as prominent target in biomedical research due to its involvement various diseases, including cancer and autoimmune disorders; even though recent addition MHC, interaction between HLA-C KIR is crucial for immune responses, particularly viral infections. This review provides an overview of structure, origin, function,...