Multiple sclerosis is a chronic inflammatory disease of the central nervous system, characterized by an aberrant activation of the immune system and combining demyelination with neurodegeneration. Studies on experimental models of multiple sclerosis revealed immunomodulatory and immunosuppressive properties of mesenchymal stem cells. Clinical trials using mesenchymal stem cells therapy in multi...

four known flavonoids: quercetin 3-o-β-d-rutinoside (q3rut), myricetin 3-o-β-d-galactopyranoside (m3gal), quercetin 3-o-β-d-galactopyranoside (q3gal) and quercetin 3-o-β-d-glucopyranoside (q3glc), for the first time were isolated from aerial parts of euphorbia microsciadia. the chemical structure of them was elucidated on the basis of 1 and 2 d-nmr spectra and different spectroscopic techniques...

objective: homalium letestui pellegr (flacourtiaceae) is used in traditional medicine in parts of nigeria for the treatment of malaria, ulcer, and inflammatory diseases and as an aphrodisiac. this investigation was aimed to evaluate the cytotoxic, immunomodulatory, and antileishmanial properties of stem extract and fractions of homalium letestui (h. letestui). materials and methods: cytotoxic a...

Due to their immunomodulatory and chemotactic properties, hMSC are being explored to treat immune-related diseases. For their use in human therapies, it is necessary to culture hMSC in xeno-free conditions. In this study, the impact that a xeno-free medium based on a human plasma derivate has on these properties was analysed. Bone marrow-derived hMSC preserved their immunosuppressive and immuno...