AIMS To determine the incremental cost effectiveness of nicotine replacement therapy (NRT), bupropion and varenicline for preventing relapse to smoking when used by abstinent smokers DESIGN SETTING AND PARTICIPANTS Cohort simulation and sensitivity analyses combining cost and health service data with systematic review estimates for the effectiveness of NRT, bupropion and varenicline when used...

The authors examine the incremental cost-effectiveness of using quadrivalent influenza vaccines rather than trivalent vaccines in various age and risk groups in England, finding that use of quadrivalent vaccines in pediatric groups was most likely to be cost-effective (i.e., with the greatest incremental cost per quadrivalent dose), with extending quadrivalent vaccination to high risk adults or...

BACKGROUND The objective of this analysis was to determine the value (incremental cost/increment benefit) of a brain LITT system versus employing current surgical options recommended by NCCN guidelines, specifically open resection (i.e. craniotomy) methods or biopsy (collectively termed CURRENT TREATMENTS) in patients where maximal safe resection may not be feasible. As has been demonstrated in...

BACKGROUND Patients with severe aortic stenosis and coexisting non-cardiac conditions may be at high risk for surgical replacement of the aortic valve or even be no candidates for surgery. In these patients, transcatheter aortic valve implantation (TAVI) is suggested as an alternative. Results of the PARTNER (Placement of AoRTic TraNscathetER Valve) trial comparing the clinical effectiveness of...

OBJECTIVE To determine the cost effectiveness of two view mammography at incident screens. DESIGN Incremental cost effectiveness analyses recognising differences in current reading policy, based on effectiveness data from an observational study. SETTING Breast screening programmes in England and Wales. MAIN OUTCOME MEASURES Health service costs, cancers detected, incremental cost effectiv...

BACKGROUND Abciximab reduces the number of ischemic events in patients undergoing angioplasty compared to standard therapy. Coronary stenting reduces the need for repeat procedures. Abciximab or stents individually are considered cost effective interventions. There is a need to quantify the economic value of the combination of abciximab and stenting over stenting alone. METHODS A decision ana...

When using chemotherapy in patients with a short life expectancy, outcomes such as symptom improvement or clinical benefit receive increasing attention. Outcomes of subjective benefit to the patient can be rated as a utility in order to perform health economic analyses and comparisons with other treatment conditions. A cost-utility analysis has been performed alongside a prospective randomised ...

Single point incremental sheet metal forming is a sheet metal forming process that forms products without the complex dies and tools with low cost. In this study, the incremental sheet metal forming process has been experimentally investigated on the explosively-welded Al/Cu bimetal sheets. Also, the effects of process parameters, such as arrangement of layer`s bimetal, tool diameter and tool p...

Objectives: We aimed to compare the use of cost-effectiveness analysis and cost-utility analysis in health technology assessment in Poland. Methods: We analyzed all the submissions (155) made to the Polish Agency for Health Technology Assessment in the period 2007 to 2011, with 316 intervention-comparator comparisons reporting incremental cost-effectiveness ratios (ICERs) or incremental cost-ut...