Nucleophosmin (NPM1) is a multifunctional protein that controls cell growth and genome stability via a mechanism that involves nucleolar-cytoplasmic shuttling. It is clear that NPM1 also contributes to the DNA damage response, yet its exact function is poorly understood. We recently linked NPM1 expression to the functional activation of the major abasic endonuclease in mammalian base excision r...

Epidemiological studies have revealed a complex association between human genetic variance and cancer risk. Quantitative biological modeling based on experimental data can play a critical role in interpreting the impact of genetic variation on biochemical pathways relevant to cancer development and progression. Defects in human DNA base excision repair (BER) proteins can reduce cellular toleran...

In this paper, the bit error rate (BER) of 16 differential amplitude phase shift keying (16DAPSK) modems in future mobile communication system is derived analytically. The channel employed in this paper is the frequency-selective and fast Rayleigh fading channel, corrupted by cochannel interference (CCI) and additive white Gaussian noise (AWGN). Exact expressions for the probability distributio...

lymphatic filariasis (lf), a nematode disease transmitted by arthropod vectors, is repeatedly reported in immigrant population. this disease is not endemic in iran; however, different species of mosquitoes, capable of transmission of parasite mi-crofilaria, are distributed in the country. hereby, incidental detection of an im-ported case of lf due to wuchereria bancrofti in an indian worker in ...

Cellulosic Ž bers have been used as cost-cutting Ž llers in plastic industry. Among the various factors, the Ž nal performance of the composite materials depends to a large extent on the adhesion between the polymer matrix and the reinforcement and therefore on the quality of the interface. To achieve optimum performance of the end product, sufŽ cient interaction between the matrix resin and th...

In order to investigate the electrophysiology of the human internal anal sphincter and two current concepts of sphincter function, simultaneous manometric and electrical recordings were made from circular smooth muscle of the internal anal sphincter in the resting state and during reflexly induced sphincter relaxation. Three groups were studied: seven normal subjects, 25 patients with functiona...

This paper presents a new technique to improve the performance of OFDM systems with nonlinear amplifiers. This method aims to achieve good balances between PAPR and BER at low computer cost. A performance and complexity comparison with known techniques for BER reduction is presented. The results show that the proposed method has lower computational complexity (about 33% fewer multiplications), ...

The molecular hallmark of the Philadelphia (Ph) translocation in CML is a rearrangement between the e-abl oncogene and a gene provisionally called ber [7, 11, 13, 19]. As a consequence of this genomic recombination on the Ph chromosome, CML cells transcribe a chimeric 8.5-kb RNA species, consisting of both 5'ber and e-abl sequences [6, 10, 20], that is translated into a p 210 abl protein [15, 1...

Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens. This fundamental and essential function of BER not only necessitates tight control of the continuous...