Individuals with multiple osteochondromas (MO) demonstrate shortened long bones. Ext1 or Ext2 haploinsufficiency cannot recapitulate the phenotype in mice. Loss of heterozygosity for Ext1 may induce shortening by steal of longitudinal growth into osteochondromas or by a general derangement of physeal signaling. We induced osteochondromagenesis at different time points during skeletal growth in ...

Microtubules are an essential physical building block of cellular systems. They organized using specific crosslinkers, motors, and influencers nucleation growth. With the addition anti-parallel microtubule pattern goes through transition from fan-like structures to homogeneous tactoid condensates in vitro. Tactoids reminiscent biological mitotic spindles, cell division machinery. To accomplish ...

Myenteric plexus neurons derived from neonatal guinea pigs, when exposed to serum, demonstrated a characteristic pattern of growth, including a proliferating outgrowth zone of glial cells, peripheral extension of dendritic processes, and progressive dendritic growth. Serum effects upon dendritic growth, measured morphometrically, was strongly dose- and temporally dependent. Dendritic density wa...

Introdouction: This study investigated the potential relationship between vertical facial growth patterns and airway volumes in a sample of Iranian adult patients. Materials and methods: This cross sectional study was conducted on 72 adult patients (44 females, 28 males), ages 18– 45 years, who had been referred to the Department of Oral and Maxillofacial Radiology at the Shiraz Univer...

Background: Hospitals may be under pressure to implement cost saving strategies regarding prosthesis choice. Thismay involve the use of components which are not the first preference of individual surgeons, or those they have littleexperience with. We aim to examine the effect of standardizing the type of femoral stem used in a single trust, anddetermine whether this is safe practice, particular...

BACKGROUND Clinical studies suggest that testosterone (T) plays an important role in the male predominance of the clinical manifestations of the Brugada syndrome (BS). However, no statistically significant correlations have been observed between T levels and electrocardiogram (ECG) parameters in the BS patients. We investigated whether the hormonal pattern and the variation within CAG repeat po...