Background. Epithelial dysplasia is categorized as conjunctival/corneal intraepithelial neoplasia which is a precancerous lesion. The lesion is usually developed at the limbal region and grows towards central cornea in association with neovascularization into the lesion. Here, we report a case of isolated nonvascularized corneal epithelial dysplasia surrounded by normal corneal epithelium with ...

Precancerous epithelial lesions are sites of uncontrolled cellular proliferation, generated by irreversible genetic changes. Not all of these lesions progress to invasive cancer, some may even regress, but early detection of abnormal cells can be crucial for survival of the patient. Diagnosis is mainly performed by using morphological parameters. Proliferation markers can facilitate the analysi...

Autofluorescence bronchoscopy (AFB) is one of the newly developed diagnostic tools to detect the pre-cancerous lesions in the bronchial tissue. The utility of DLight/AFB in the detection of pre-cancerous lesions was compared to the standard white light bronchoscopy (WLB). In 113 patients (male 106, female 7), who visited hospital for evaluation of lung cancer, WLB and AFB were done and 364 biop...

UNLABELLED Pap testing is considered to be the best screening tool for cervical cancer but there is currently great interest in the possible application of human papilloma virus (HPV) testing to supplement Pap screening for cervical cancer. AIM To determine the prevalence of high-risk HPV types in the studied population and to explore the association between high-risk HPV types and cervical d...

BACKGROUND Deregulation of β-catenin is associated with malignant transformation; however, its relationship with potentially malignant and malignant oral processes is not fully understood. The aim of this study was to determine and compare the nuclear β-catenin expression in oral dysplasia and oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS Cross sectional study. Immunodetection of ...

OBJECTIVE To study the long term risk of invasive cancer of the cervix or vagina after treatment for cervical intraepithelial neoplasia grade 3. DESIGN Prospective cohort study. SETTING Swedish cancer registry. PARTICIPANTS All women in Sweden with severe dysplasia or cervical carcinoma in situ (equivalent to cervical intraepithelial neoplasia grade 3) treated during 1958-2002 (n=132,493)...

A rare case of anal intraepithelial neoplasia arising in an inflammatory cloacogenic polyp is reported. While the occurrence of neoplasia complicating benign anal conditions is recognised, this case re-emphasises the need for careful histological examination of all perianal lesions.

Background Cancer cervix is a major health problem in India, accounting for 26.1-43.8% of all cancers in Indian women. Dysplasia on Pap smear has been reported in 15-40% of HIV positive women which is 10-11 times higher than those observed among HIV negative women. Patients with persistent inflammatory Pap smears harbor high proportion of HPV infection and cervical intraepithelial neoplasia (20...

Recognition of cervical dysplasia or human papilloma virus (HPV) effect can be a very difficult task, particularly in those cases with "borderline" morphologic features. Interpretation in such cases is highly subjective, and it is not surprising that interobserver reproducibility of HPV effect and mild squamous dysplasia is poor. Because the clinical (and social) implications of these diagnoses...

Background The regression discontinuity design (RDD) is a quasi-experimental approach used to avoid confounding bias in the assessment of new policies and interventions. It is applied specifically in situations where individuals are assigned to a policy/intervention based on whether they are above or below a pre-specified cut-off on a continuously measured variable, such as birth date, income o...