purpose: to determine the prevalence of various types of conjunctival lesions, at a tertiary ophthalmic center in fars province, south of iran. methods: histopathologic slides and medical records of conjunctival lesions submitted to the pathology department of khalili hospital, shiraz, iran was reviewed from april, 2009 to july, 2013. the histopathologic diagnoses were categorized into benign, ...

Background: According to WHO-Cervical Cancer is the fourth most common cancer in women. This study evaluated expression of P16 cervical intraepithelial lesion and carcinoma its correlation with tumour grade, age, etc.Material Methods: 106 histopathologically proven Cervical Intraepithelial lesions (CIN) invasive cases were subjected IHC for p16. Result: Most age group involved was 51-60years. B...

StochaStic Modeling of tuMor ProgreSSion: gi tract cancerS aS a ParadigM Historically, the founding paradigm has been that cancers of the gastrointestinal tract are preceded by a pre-invasive stage of intraepithelial neoplasia. From the morphological standpoint the term “dysplasia” has been conventionally applied to the collection of changes in cellular morphology and tissue architecture that d...

The aim of the study was to evaluate the justification of Croatian modification of Bethesda classification after thirteen years of its application, answering the question if the subclassification of high-grade squamous intraepithelial lesion (HSIL) into cervical intraepithelial lesion (CIN) grade 2 (CIN2) and grade 3 (CIN3) is cytologically real and clinically justified. The retrospective study...

The theoretical and practical reasons for replacing the terms "cervical dysplasia" and "cervical carcinoma in situ" by the single diagnostic entity of "cervical intraepithelial neoplasia" are reviewed and the advantages and drawbacks of this newer terminology discussed. The histological characteristics and cytological features of the various grades of cervical intraepithelial neoplasia are desc...

Metastatic carcinoma of urogenital origin is a common cause of mortality in free-ranging California sea lions (Zalophus californianus). The etiology of this cancer is likely multifactorial, with viral infection, genetic factors, and exposure to environmental organochlorine contaminants possible contributing factors. In this study, expression of estrogen receptor alpha (ER alpha), progesterone r...

Cervical cancer serves as a biologic and an epidemiologic model for anal carcinoma and its precursors. The current incidence of cervical cancer in the United States is approximately 8 cases per 100,000 people. The incidence of anal cancer in men who had sex with men (MSM) prior to the HIV epidemic was 35 per 100,000—an incidence rate similar to that of cervical cancer before routine Pap testing...

Conjunctival squamous cell carcinoma (SCC) can develop from carcinoma in situ or severe dysplasia known as conjunctival intraepithelial neoplasia (CIN). Conjunctival intraepithelial neoplasia and SCC are histopathologically well-defined conditions. However, it is difficult to determine the grading of dysplasia by clinical morphologic findings. Recently, proliferating cell nuclear antigen (PCNA)...

Introduction. In the period from 2010 to 2021, 150 patients were treated with loop electrosurgical excision of cervix at Special Gynecological Hospital ?Genesis?, Novi Sad. The aim this study was present results treatment, incidence complications and recurrences after in treatment cervical dysplasia. Material Methods. group A included 87 (58%) intraepithelial neoplasia, control B 63 (42%) benig...

BACKGROUND Bronchial intraepithelial lesions may be precursors of central airway lung carcinomas. Identification and early treatment of these preinvasive lesions might prevent progression to invasive carcinoma. METHODS We systematically reviewed the literature to develop evidence-based recommendations regarding the diagnosis and treatment of intraepithelial lesions. RESULTS The risk and tim...