BACKGROUND Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we are lacking data on burn shock. Our objective was to assess the hydrocortisone-induced transcriptional modulation in severe burn shock, partic...

BACKGROUND AND PURPOSE Hyponatremia is common after aneurysmal subarachnoid hemorrhage (SAH). It is caused by natriuresis, which induces osmotic diuresis and decreases blood volume, contributing to symptomatic cerebral vasospasm (SCV). Hypervolemic therapy to prevent SCV will not be efficient under this condition. We conducted a randomized controlled trial to assess the efficacy of hydrocortiso...

AIM To characterize the prescribing patterns for hydrocortisone for patients with septic shock and perform an exploratory analysis in order to identify the variables associated with better outcomes. METHODS This prospective cohort study included 59 patients with septic shock who received stress-dose hydrocortisone. It was performed at 2 critical care units in academic hospitals from June 1st,...

background and objectives: hydrocortisone is widely used in septic shock cases resistant to fluid and vasopressor therapy. it may result in increased blood pressure and survival. however the efficacy is no established among patients with severe burn and septic shock. accordingly it was assessed in this study. materials and methods: the patients older than 14 years of age with resistant septic s...

introduction: phonophoresis is the use of ultrasound to enhancing cellular drug delivery through the skin. in this study the effect of clobethasole and hydrocortisone ointments phonophoresis on pain, knee osteoarthritis and some other symptoms was studied. methods: an experimental single blind randomized clinical trial (rct) was used. an available sampling technique was used for selection of pa...

background depression and sleep disorders are more prevalent among rotational shift workers than regular day workers. people with sleep disorders have higher inflammatory and pre-inflammatory cytokines than those in the control group. objectives the present study was conducted to investigate serum level of high sensitivity c-reactive protein (hscrp), interleukin-6 (il-6) and cortisol among depr...

BACKGROUND Reports of mild hypocortisolism in chronic fatigue syndrome led us to postulate that low-dose hydrocortisone therapy may be an effective treatment. METHODS In a randomised crossover trial, we screened 218 patients with chronic fatigue. 32 patients met our strict criteria for chronic fatigue syndrome without co-morbid psychiatric disorder. The eligible patients received consecutive ...

Glucocorticosteroid therapy results in an increase in the number of circulating neutrophils and a decrease in the number of eosinophils. Utilizing the double layer soft agar technique, we examined the effect of physiologic to pharmacologic concentrations of hydrocortisone on the proliferation of human neutrophil progenitors and eosinophil progenitors from peripheral blood and bone marrow. When ...

To analyse if hydrocortisone could modify the in vitro susceptibility of Aspergillus fumigatus to antifungal drugs, we developed a procedure to test the susceptibility of an A. fumigatus strain to amphotericin B and itraconazole, grown in the presence and in the absence of hydrocortisone. Conidia were germinated in the presence or the absence of hydrocortisone in Czapek medium without antifunga...

The management of congenital adrenal hyperplasia due to 21-hydroxylase (CYP21) deficiency requires glucocorticoid substitution with oral hydrocortisone given twice or thrice daily. In paediatric practice little is known of the bioavailability of oral hydrocortisone tablets used in these patients. The aim of this study was to assess the bioavailability of oral hydrocortisone and to evaluate curr...