the synthesis and single-crystal x-ray structure determination of the title compound (dinitrato) (1,4,8,11 -tetra-azaandecane) lead(ii) is described. crystals are monoclinic, p2 /ca= 10.271 (2)?,b= 13.524(4) ?,c= 11.298(6) ?,?=94.68(3),2=4,r,rw, 0.036 and 0.041, respectively. the lead atom is eight-coordinate [pb-n, 2.44 (2) - 2.55 (1)], [pb-0,2.87 (1) - 3.06 (2)].

In the present study, 13 bromopyrrole alkaloids, including the oroidin analogs hymenidin (2), dispacamide B (3) and dispacamide D (4), stevensine (5) and spongiacidin B (6), their derivatives lacking the imidazole ring bromoaldisin (7), longamide B (8) and longamide A (9), the dimeric oroidin derivatives sceptrin (10) and dibromopalau'amine (11), and the non-oroidin bromopyrrolohomoarginin (12)...

Cyanobacterial cyclopeptides, including microcystins and nodularins, are considered a health hazard to humans due to the possible toxic effects of high consumption. From a pharmacological standpoint, microcystins are stable hydrophilic cyclic heptapeptides with a potential to cause cellular damage following uptake via organic anion-transporting polypeptides (OATP). Their intracellular biologica...

This paper presents a discussion of fundamental problems of the speciation analytics of organometallic compounds occurring at low concentration levels in samples involving a complex matrix. It points out differences in analytical procedures for speciation analyses and those for determinations of total contents of a metal present in the studied sample in a number of different species.

Most of the proteins are synthesized as inactive proforms requires a proteolytic process to render them active. Proprotein convertases (PCs) are a family of serine proteases capable of activating substrates. Furin is a family of subtilisin-like proprotein convertases (PCs) which is calcium-dependent serine endoprotease. It is enriched in Golgi apparatus that cleaves protein to active or mature ...

The Zika virus disease (ZVD) currently spreading around the globe has no known treatment available. A database of Zika-related genes (N=69) was subjected to chemoinformatics approaches using the canSAR protein annotation tool. Ligand-based druggability analysis of the database of genes identified thirtyfive druggable targets encompassing adhesion molecules, cytokines, enzymes, growth factors an...

:\<Iass spectra of letramethyl and tetraethyl lead and of dimethyl, diet llyl, and di-n-butyl mercury were obtained with a Co nsolidated 21102 mass spec trometer. Monoisotopic spectra were calculated by using the isotopic abundance derived from eac h spectrum. A variation in the lead isotope abundance was observed in the commercially available lead a lkyls. No variation was observed a mong t he...

Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective properties. Dietary exposure to benzopyrones is significant as these compounds...

The bacterial genus Corynebacteria contains several pathogenic species that cause diseases such as diphtheria in humans and "cheesy gland" in goats and sheep. Thus, identifying new therapeutic targets to treat Corynebacteria infections is both medically and economically important. CG2496, a functionally uncharacterized protein from Corynebacterium glutamicum, was evaluated using an NMR ligand-a...