In this study, Channa punctatus was treated with sub-lethal concentration of cypermethrin (6.6 μg/L) for 5, 10 and 15 days and its effect on total CYP 450 and the activity of hepatic CYP450 isoforms measured. Total CYP450 content and CYP1A mediated EROD activity was significantly induced (p<0.05) in all three treated groups compared to control whereas only 15 days treated group showed significa...

The aim of this study was to investigate the effects of iodine and/or selenium deficiency on cerebral enzyme levels/ activities responsible for xenobiotic metabolism on rats. Three-week old male Wistar rats were used and feeding period was 7-weeks. Selenium deficiency was introduced by a diet containing <0.005 mg/kg selenium, and iodine deficiency was produced by sodium perchlorate containing d...

Cobaltous chloride (CoCl2) caused very marked decreases of cytochrome P-450, b5 and total heme contents and an increase of heme oxygenase activity. On the contrary, phenobarbital (PB) increased hepatic drug-metabolizing enzymes, but the total heme content remained unchanged. On the other hand, amitriptyline (AMT) caused a marked increase of delta-aminolevulinic acid (delta-ALA) synthetase activ...

The effect of trivalent and hexavalent chromium compounds on the activities of selective hepatic drug metabolising enzymes and renal enzymes, in relation to the duration of exposure and tissue concentration of the metal in rats, was investigated to evaluate their potential toxicity. The activity of hepatic aniline hydroxylase decreased more markedly than that of amino N-demethylase on treatment...

1. Male Wistar rats were given isoenergetic, semi-synthetic diets deficient in thiamin, riboflavin, pyridoxine or all the B-vitamins. 2. In rats given these deficient diets the 'sleeping time' induced with pentobarbital (PB) and the 'paralysis time' with zoxazolamine (Zz) were prolonged. 3. The tolerance effect against both drugs was nearly independent of the levels of B-vitamins in the diets. ...

Three juvenile hormone analogs were found to be in vitro inhibitors of rat liver microsomal oxidases. Aniline hydroxylase reactions gave apparent inhibition constants of 8 X 10-5 M and 1.4 X 10 4 M for ( E ) -4[( 6,7 -epoxy-3,7 dimethyl2monenyl)oxy] 1,2(methylenedioxy) benzene and (E) 4 [(6,7 epoxy 3 ethyl 7 methyl 2 noneny1)oxyl 1,2 (methylenedioxy)benzene, respectively. (E)-6,7-Epoxy-l-(p-eth...

In this study the data on 115 cases of congenital adrenal hyperplasia (CAH) who were followed in the Pediatric Endocrine Clinic at Nemazee Hospital, Shiraz will be reported. Among these cases 51 were male and 64 female. The most common type of CAH in these patients was the salt-losing type of 21 -hydroxylase deficiency (85 .2%). ll-hydroxylase deficiency was present in 13.04% of patients. ...

Preliminary studies have been conducted on various parameters in order to assess the possible and relative toxicities of a number of metallic salts. Upon oral administration in lethal-dose experiments, two soluble Pt4+ salts were more toxic than the other salts tested. Following intraperiotneal injection in lethal-dose experiments, PbCl2 was less toxic than several of the soluble or partially s...

Electrical sensitivity of a boron nitride nanotube (BNNT) was examined toward aniline (C6H5NH2) molecule by using density functional theory (DFT) calculations at the B3LYP/6-31G (d) level, and it was found that the adsorption energy (Ead) of aniline on the pristine nanotubes is a bout -19.03kcal/mol. But when nanotube has been doped with Si and Al ato...