INTRODUCTION Many patients in maintenance treatment programs for opioid dependence are parents to underage children. OBJECTIVE The aim of this study was to explore how parents who are regular patients in maintenance treatment perceive their parenthood. METHODS The study used a qualitative approach. The informants were recruited by staff at a substance abuse clinic in Sweden. Criteria for in...

The evidence-based pharmacotherapy of panic disorder continues to evolve. This paper reviews data on first-line pharmacotherapy, evidence for maintenance treatment, and management options for treatment-refractory patients. A Medline search of research on pharmacotherapy was undertaken, and a previous systematic review on the evidence-based pharmacotherapy of panic disorder was updated. Selectiv...

Depression in later life is usually a recurrent illness and often a chronic one, associated with increased health care utilization, amplification of the disability born of concurrent medical illness, decreased quality of life, increased risk for suicide, and cognitive impairment. The good news, however, is that maintenance treatments work and have a demonstrably positive impact on long-term ill...

Functional constipation is a common healthcare problem among children worldwide and accounts for high healthcare usage and costs. Functional constipation is a clinical diagnosis; the evaluation primarily consists of a thorough medical history and a complete physical examination. Additional investigations are not necessary in most cases. Treatment consists of non-pharmacological and pharmacologi...

This article describes the history of the heated legal controversy in Germany about prescribing medicinal narcotics. The professional corporations of medical doctors have claimed a right to govem the interpretation and definition of legal terms and for a long time resisted the clinical insights and practical experience about maintenance treatment that had been gathered from abroad. The next log...

Approaches to improving the chemotherapy of Hodgkin's dis ease are presented and discussed: The dose-response (both antitumor effect and toxicity) curve for ohemotherapeutic agents is steep. Prior treatment and duration of disease have an adverse effect on response to chemotherapy. Continued treatment during remission (maintenance treatment) will prolong the duration of remission. Combined trea...

AIMS To compare the efficacy of slow-release oral morphine (SROM) and methadone as maintenance medication for opioid dependence in patients previously treated with methadone. DESIGN Prospective, multiple-dose, open label, randomized, non-inferiority, cross-over study over two 11-week periods. Methadone treatment was switched to SROM with flexible dosing and vice versa according to period and ...

We have carried out the largest randomised trial to date of newly diagnosed myeloma patients, in which lenalidomide has been used as an induction and maintenance treatment option and here report its impact on second primary malignancy (SPM) incidence and pathology. After review, 104 SPMs were confirmed in 96 of 2732 trial patients. The cumulative incidence of SPM was 0.7% (95% confidence interv...