Many Asian subjects were seen in London in the early 1970s with megaloblastic anaemia; in a majority of cases, this was dietary in origin. Pernicious anaemia occurs in Asians, but the incidence is probably lower than in Caucasians. Megaloblastic anaemia is now less common in this group, but a population survey in Punjabi females in the late 1970's showed anaemia in 32%, and one or more features...

Normal human peripheral blood lymphocytes cultured with phytohemagglutinin in folate-free RPMI 1 640 medium supplemented with normal human serum exhibit megaloblastic maturation. These changes are accompanied by a decrease in intracellular folate content. and when compared to folate-replete cells. reveal increased 3H-thymidine incorporation into DNA together with a decreased inhibitory effect o...

Normal human peripheral blood lymphocytes cultured with phytohemagglutinin in folate-free RPMI 1 640 medium supplemented with normal human serum exhibit megaloblastic maturation. These changes are accompanied by a decrease in intracellular folate content. and when compared to folate-replete cells. reveal increased 3H-thymidine incorporation into DNA together with a decreased inhibitory effect o...

LTHOUGH megaboblastic anemia of pregnancy is considered mainly as a folic acid deficiency anemia, since this vitamin induces remission in most cases, its mechanism of production is still obscure. Dietary deficiency has been claimed to be the principal cause. However, this anemia has been observed in well-to-do women whose diet was satisfactory. Some other factors such as gastrointestinal upset,...