this paper presents an efficient global meta-model building technique for solving high fidelity multidisciplinary design optimization (mdo) problems. the main difficulties associated with mdo are often characterized by interdisciplinary couplings, high computational cost of an analysis in individual disciplines and a large number of design variables and constraints. these issues result in very ...

Teachers’ Experiences in Flipped Classroom South-East Asian Countries: A Meta-Synthesis. Objective: This study aimed to meta-synthesize the teachers’ experiences utilizing flipped classrooms across countries. Methods: Fifteen (15) out of 1,118 studies were included from various accessible academic databases Publish or Perish software which was scrutinized using a set inclusion and exclusion cri...

This paper describes a class of decision procedures that we have found useful for efficient, domainspecific deductive synthesis. These procedures are called closure-based ground literal satisfiability procedures. We argue that this is a large and interesting class of procedures and show how to interface these procedures to a theorem prover for efficient deductive synthesis. Finally, we describe...

OBJECTIVES Synthesizing qualitative research is an important means of ensuring the needs, preferences, and experiences of patients are taken into account by service providers and policy makers, but the range of methods available can appear confusing. This study presents the methods for synthesizing qualitative research most used in health research to-date and, specifically those with a potentia...

The N-terminal 25 residue segment of human surfactant protein B (SP-B(1-25)) was synthesised in 26% yield by manual Fmoc solid-phase peptide synthesis (Fmoc SPPS) using low-loading Fmoc-Gly-Wang resin. Substantial oxidation of Met(21) occurred during the synthesis, and the addition of Bu(4)NBr to a TFA/water/EDT/TIS cleavage cocktail enabled facile reduction of Met(O)(21)-SP-B(1-25) to SP-B(1-2...

Background and objectives: Although nutrition is important to bone health, the impact of different dietary patterns on density fracture unclear. The aim this study was synthesise conflicting evidence from observational studies determine associations empirically derived with in healthy adults. Method: A systematic review (PROSPERO CRD42017071676) meta-analysis where possible (for hip fractur...

In this paper a compositional model for reflective agents is proposed within which reasoning about observation, assumption making and communication; an agent’s own information state and reasoning processes; other agents’ information states and reasoning processes, and combinations of these types of reflective reasoning are explicitly modelled. The types of knowledge needed to detect, analyse an...

COMDES-II is a component-based software framework which formally specifies the modeling concepts and constraints for distributed embedded systems in different aspects, such as component structures, interaction, hierarchy, etc. The paper presents an overview of the design philosophies of COMDES-II in the related aspects and a generative programming approach developed to enable the engineering ap...