نتایج جستجو برای: mex tool

تعداد نتایج: 362984  

Journal: :Toxicon : official journal of the International Society on Toxinology 2005
P Diaz G Chowell G Ceja T C D'Auria R C Lloyd C Castillo-Chavez

Scorpionism is an endemic public health problem in Mexico [Hoffmann, C.C., 1936. La distribucion geografica de los alacranes peligrosos en la Republica Mexicana. Bol. Inst. Hygiene Mex. 2, 321; Hoffmann, C.C., Nieto, D.R., 1939. Segunda contribucion al conocimiento de los alacranes mexicanos. Anal. Inst. Biol. 10, 83-92; Mazzoti, L., Bravo-Becherelle, M.A., 1963. Scorpionism in the Mexican Repu...

Journal: :British journal of pharmacology 1999
J F Desaphy D Conte Camerino C Franchini G Lentini V Tortorella A De Luca

1 The antiarrhythmic drug mexiletine (Mex) is also used against myotonia. Searching for a more efficient drug, a new compound (Me5) was synthesized substituting the methyl group on the chiral carbon atom of Mex by an isopropyl group. Effects of Me5 on Na+ channels were compared to those of Mex in rat skeletal muscle fibres using the cell-attached patch clamp method. 2 Me5 (10 microM) reduced th...

Journal: :Molecular pharmacology 2000
A De Luca F Natuzzi J F Desaphy G Loni G Lentini C Franchini V Tortorella D C Camerino

On the basis of the information about drug receptor on voltage-gated sodium channels, mexiletine (Mex) analogs with substitutions at either the asymmetric carbon atom or the aromatic ring were synthesized as pure enantiomers. The compounds were tested in vitro for their ability to produce voltage- and use-dependent block of sodium currents (I(Na)) of frog muscle fibers by the vaseline-gap volta...

2013
Florencia Cano Paul J. Lehner

By providing ligands for Cytotoxic T-Lymphocytes (CTL) as well as Natural Killer (NK) cells, the HLA-A/B/C MHC class I molecules (MHC-I) play a central role in both innate and adaptive immunity. In addition to CTL-mediated recognition of MHC-peptide complexes, cell surface expression of MHC-I is closely monitored by NK cells, whose killer-cell immunoglobulin-like receptors encode activatory and...

2009
A. Dumke M. Spiegel S. van Gasselt G. Neukum

Introduction: Since December 2003, the European Space Agency’s (ESA) Mars Express (MEX) orbiter has been investigating Mars. The High Resolution Stereo Camera (HRSC), one of the scientific experiments onboard MEX, is a pushbroom stereo color scanning instrument with nine line detectors, each equipped with 5176 CCD sensor elements. Five CCD lines operate with panchromatic filters and four lines ...

Journal: :Discrete Applied Mathematics 2012
Vladimir Gurvich

For any non-negative integers a and b, we consider the following game WY T (a, b). Given two piles that consist of x and y matches, two players alternate turns; a single move consists of a player choosing x′ matches from one pile and y′ from the other, such that 0 ≤ x′ ≤ x, 0 ≤ y′ ≤ y, 0 < x′ + y′, and [min(x′, y′) < b or |x′ − y′| < a]. The player who takes the last match is the winner in the ...

2017
Jean-Loup Bertaux Brigitte Gondet Franck Lefèvre Jean-Pierre Bibring Franck Montmessin J. L. Bertaux B. Gondet F. Lefèvre J. P. Bibring F. Montmessin

Journal: :Cell reports 2016
Yusuke Yamazumi Oh Sasaki Mitsuru Imamura Takeaki Oda Yoko Ohno Yumi Shiozaki-Sato Shigenori Nagai Saki Suyama Yuki Kamoshida Kosuke Funato Teruhito Yasui Hitoshi Kikutani Kazuhiko Yamamoto Makoto Dohi Shigeo Koyasu Tetsu Akiyama

Allergic airway inflammation is one of the primary features of allergic asthma. Interleukin-33 (IL-33) is recognized as a key pro-inflammatory cytokine that mediates allergic airway inflammation, and its expression is elevated in this condition, but little is known about the regulatory mechanisms underlying IL-33 induction. Here, we show that the RNA binding protein Mex-3B plays a critical role...

1999
Matthias Anlauff Philipp W. Kutter Alfonso Pierantonio

In this paper, we describe the tool Gem-Mex, supporting Montages, a visual formalism for the speci cation of (imperative/object oriented) programming languages. Introduction Montages [KP97] form a graphical notation for expressing the syntax and semantics of imperative and object oriented languages. Every syntactic construct has its meaning speci ed by a Montage, which consist of a diagram de n...

Journal: :American Journal of Science 1903

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