results following ectopic expression of mir-375, sox2ot and sox2 expression analysis revealed a significant decrease in their expression level (p < 0.05) in nt-2 cells compared to the control. cell cycle analysis following ectopic expression of mir-375 in the nt-2 cells using propidium iodine staining revealed significant extension in sub-g1 cell cycle. conclusions this is the first report to s...

The continued growth of MIR is motivating more complex annotation data, consisting of richer information, multiple annotations for a given task, and multiple tasks for a given music signal. In this work, we propose JAMS, a JSON-based music annotation format capable of addressing the evolving research requirements of the community, based on the three core principles of simplicity, structure and ...

Microblogging services, such as Twitter, have risen enormously in popularity during the past years. Despite their popularity, such services have never been analyzed for MIR purposes, to the best of our knowledge. We hence present first investigations of the usability of music artist-related microblogging posts to perform artist labeling and similarity estimation tasks. To this end, we look into...

Huntington's disease (HD) is caused by the expansion of N-terminal polymorphic poly Q stretch of the protein huntingtin (HTT). Deregulated microRNAs and loss of function of transcription factors recruited to mutant HTT aggregates could cause characteristic transcriptional deregulation associated with HD. We observed earlier that expressions of miR-125b, miR-146a and miR-150 are decreased in STH...

Age related macular degeneration (AMD) is the leading cause of blindness among people aged 50 and over. Retinal deposition of amyloid-β (Aβ) aggregates in AMD patients has suggested a potential link between AMD and Alzheimer's disease (AD). We have evaluated the differential retinal expression profile of miRNAs in a rat model of AMD elicited by Aβ. A serum profile of miRNAs in AMD patients has ...

background: early detection is a key to survival for gastric cancer. molecular markers such as mirna (microrna) can have great importance in the early diagnosis of gastric cancer. expression of mir-21 and mir-221 are deregulated in many types of human cancers. this study aimed to investigate the differences in mirna expression patterns within the iranian population. methods: total rna was extra...

The objective of this study was to determine the expression of miR-483 and miR-483* and the relationship among them, their host gene (Igf2), and other cytokines in a murine model of renal fibrosis. The extent of renal fibrosis was visualized using Masson staining, and fibrosis was scored 3 days and 1 and 2 weeks after unilateral ureteral obstruction (UUO). Expression of miR-483, miR-483* and va...

miR-133a and miR-1 are known as muscle-specific microRNAs that are involved in cardiac development and pathophysiology. We have shown that both miR-1 and miR-133a are early and progressively upregulated during in vitro cardiac differentiation of adult cardiac progenitor cells (CPCs), but only miR-133a expression was enhanced under in vitro oxidative stress. miR-1 was demonstrated to favor diffe...