Photodynamic antimicrobial chemotherapy (PACT), as a novel and effective therapeutic modality to eradicate drug resistant bacteria without provoking multidrug resistance, has attracted increasing attention. This study examined the antimicrobial efficacy of the novel cationic amino acid-porphyrin conjugate 4I with four lysine groups against two different clinical isolated strains (drug sensitive...

Acinetobacter baumannii is an emerging multidrug-resistant nosocomial pathogen. Bacteriophages may be useful as an alternative method of treatment against this and other multidrug-resistant bacteria. Here, we present the complete genome sequence of A. baumannii phage Presley, an N4-like podophage.

Migratory birds serve as vectors by transmitting antibiotic-resistant bacteria across large distances. Here, we isolated a multidrug-resistant Stenotrophomonas pavanii strain, BWK1, from Mareca penelope feces. Analysis of the draft genome sequence of the isolated strain indicated that BWK1 harbors a class A beta-lactamase, metallo-beta-lactamase, and several multidrug efflux pumps.

The global rise of multidrug-resistant gram-negative bacteria represents an increasing threat to patient safety. From the first observation of a carbapenem-resistant gram-negative bacteria a global spread of extended-spectrum beta-lactamases and carbapenemases producing Klebsiella pneumoniae has been observed. Treatment options for multidrug-resistant K. pneumoniae are actually limited to combi...

results two- to four-fold decrease in minimum inhibitory concentration (mic) and two-fold increase in accumulation were observed for etbr in the presence of cccp for 67% (8) of 12 mdr strains. with cccp, two- to four-fold decrease in mic and 1.4- to 1.8-fold increase in the accumulation of β-lactames, tet, cip and mtz were obtained for 42% (5) of the mdr strains. six, five and three of the 12 m...

conclusions the β-lactamase disk test is appropriately sensitive to detect esbls in mdr isolates of e. coli. background most urinary tract infections (utis) are caused by escherichia coli (e. coli) species. due to infections outbreaks of e. coli strains with multiple mechanisms of resistance to β-lactam antibiotics, the sensitivity of confirmatory tests to detect the extended spectrum β-lactama...

nosocomial infections of multidrug-resistant pseudomonas aeruginosa (mdrpa) are a growing concern in hospitalized patients in burn centers. the aim of this study was to investigate the flagellin profiling and antibiotic susceptibility of p. aeruginosa isolated from burn wound infections. during 8 month study, 73 clinically p. aeruginosa isolates collected from patients hospitalized in burn ward...

The widespread of multidrug-resistant bacteria, particularly carbapenem-resistant Enterobacterales (CRE) constitutes a major public health threat worldwide, owing to the limited therapeutic options. This review will describe and uncover Saudi experience in challenge against carbapenem resistance (CR). different prevalence carbapenemase genes detected from various bacterial species were mapped f...