Background and Aims: Multiple myeloma is a malignant proliferation of plasma cells derived from a single clone. The tumor, its products and the host response lead to organ damages. Some factors that are responsible in its pathogenesis are recognized. As FMS like Tyrosine Kinase 3 receptor (FLT3) mutation has been proved as a determining factor in leukemic patients the goal of this study was to ...

Measurements were performed in 143 patients with monoclonal gammopathy of the cellular substrate in the bone marrow. including analysis of DNA and RNA content and tritiated thymidine labeling index. Aneuploidy by DNA content was present in 80% of I 1 5 patients with active multiple myeloma and in 4 of 9 patients with benign monoclonal gammopathy. but was absent in all 1 2 patients with myeloma ...

cell leukemia and closely related plasma cell discrasias. Br J Haematol (submitted) 3. Pérez-Simón JA, Garcı́a-Sanz R, Tabernero MD, Almeida J, González M, Fernández-Calvo J, Moro MJ, Hernández JM, San Miguel JF, Orfão A: Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. Blood 91:3366, 1998 4. Tricot G, Barlogie B, Jagannath S,...

objective: average age of population in the industrial countries has increased. because of aging the percent of the diseases related to the oldness such as multiple myeloma have also increased. it has both common and unique symptoms and effects. the unique effects include wide bone reabsorption. it seems necessary to understand the structure of bone marrow niche and the effects of myeloma cells...

Cytogenetic abnormalities are important clinical parameters in various types of cancer, including multiple myeloma. We developed a model to predict cytogenetic abnormalities in patients with multiple myeloma using gene expression profiling and validated it by different cytogenetic techniques. The model has an accuracy rate up to 0.89. These results provide proof of concept for the hypothesis th...

We present a rare case of a patient with delayed gastric emptying, gastric phytobezoar formation, and osteosclerotic bone lesions as an atypical association with multiple myeloma. Associated gastric features in myeloma, which include diffuse infiltration, gastric plasmacytomas, or delayed gastric emptying, are rare and have a poor prognosis.

The renal manifestations of multiple myeloma are devastating coupled with a disease as aggressive the aforementioned. Its pathophysiological understanding has been clarified over time and revealed different mechanisms by which difficult-to-manage kidney damage occurs. However, therapies that have developed made this an increasingly better prognosis. It is still therapeutic challenge to treat to...

The association between a multiple myeloma and a secondary solid tumor is not well established. Some reports showed an increased risk of secondary solid neoplasms in multiple myeloma patients, but others have not. Three cases of the synchronous occurrence of multiple myelomas and solid tumors, namely, a small cell carcinoma of the lung, an adenocarcinoma of the colon and a squamous carcinoma of...

chronic myelogenous leukemia (cml) is a stem cell disorder sometimes associated with lymphoproliferative disorders. cml may precede a lymphoproliferative disorder. there are a few reports showing associating of cml with multiple myeloma and we report a known cml case that transformed into a full-blown multiple myeloma. this patient had more than 69% of infiltrating myeloma cells in her bone mar...

plasmacytoma are extramedullary accumulations of plasma cells. most extramedullary plasmacytomas are associated with the upper respiratory tract. the lung is rarely involved. we report a rare case of lung plasmacytoma with multiple myeloma. the patient is a 60-year-old male who presented with chest pain and a lung mass visualized on ct scan. a preliminary diagnosis of occult lung cancer with wi...