A case-control comparison within the framework of the prospective, multidisciplinary PLAT Study was performed to assess whether altered baseline fibrinolytic variables were associated with an elevated risk of ischemic thrombotic events in patients with documented coronary, cerebral, and/or peripheral atherosclerotic disease. Fibrinogen, D-dimer, tissue plasminogen activator (t-PA) antigen, and ...

We explore the implications of migrants’self-selection for the determination of immigration policy in a simple model where incentives and resources to migrate vary with skills. We show how self-selection determines the response of potential migrants to immigration policy changes, which is crucial for predicting the e¤ects of such policy in the receiving country. For example, restricting immigra...

As synchrotron radiation becomes more intense, detectors become faster and structure-solving software becomes more elaborate, obtaining single crystals suitable for data collection is now the bottleneck in macromolecular crystallography. Hence, there is a need for novel and advanced crystallisation agents with the ability to crystallise proteins that are otherwise challenging. Here, an Anderson...

RNA silencing is a biochemical mechanism that regulates gene expression by post-transcriptionally activating a sequence-specific RNA degradation by three different pathways: (i) small interfering RNA (siRNA) silencing of exogenous mRNA; (ii) micro RNA (miRNA) silencing of endogenous mRNAs, and (iii) associated with DNA methylation and suppression of transcription [2]. These processes share thre...

Introduction Pulmonary nodules present a unique challenge for radiologists which includes the detection of malignancy and identification of benign disease, recommending the appropriate procedures to avoid unnecessary thoracotomy, and ensuring that excessive radiation from follow-up computed tomography (CT) examinations is kept to a minimum. Although seasoned radiologists can use an approach bas...