OBJECTIVE The PI3K/Akt signaling pathway is constitutively activated in some ovarian cancers; when activated, it promotes invasion and inhibits chemotherapy-mediated apoptosis in cancer cells. The fungal metabolite wortmannin is the currently known inhibitors that show fairly high specificity for PI3K.We examined whether PI3K/Akt activity correlates with invasion and apoptotic resistance to che...

Markers that reliably identify cancer stem cells (CSC) in ovarian cancer could assist prognosis and improve strategies for therapy. CD133 is a reported marker of ovarian CSC. Aldehyde dehydrogenase (ALDH) activity is a reported CSC marker in several solid tumors, but it has not been studied in ovarian CSC. Here we report that dual positivity of CD133 and ALDH defines a compelling marker set in ...

Rat and mouse gonadal aryl hydrocarbon hydroxylase (AHH) activity was measured and characterized in control and 3-methylcholanthrene (MC)-treated animals. The ovarian AHH activity increased 2to 3-fold in SpragueDawley, Lewis, and Brown-Norway rats following MC treatment. The same treatment decreased the testicular AHH activity in Sprague-Dawley rats. The induction of AHH activity after MC admin...

PURPOSE NRH:quinone oxidoreductase 2 (NQO2) is a homologue of NAD(P)H:quinone oxidoreductase 1 (NQO1). Despite 54% homology with human NQO1, NQO2 has little endogenous enzymatic activity. However, NQO2 has potential as a therapeutic target because the addition of the nonbiogenic electron donor dihydronicotinamide riboside (NRH) selectively potentiates the bioactivation of the alkylating agent t...

Eight different human ovarian carcinomas were shown to have 2 to 25 times higher transfer RNA methylase-specific activity and transfer RNA methylating capacity than do normal ovarian tissues. The more rapidly metastasizing, poorly differentiated carcinomas had higher transfer RNA methylase activity than did slower metastasizing, well-dif ferentiated, and intermediately differentiated carcinomas...

The distribution of gonadotropin receptor and adenylate cyclase activities has been monitored in Sepharose 6B chromatographic eluates of a Lubrol solubilized fraction of 25 day old rat ovarian tissue. The receptor was resolved from the adenylate cyclase activity. Chromatography of a gonadotropin desensitized rat ovarian preparation showed that the desensi-tized preparation contained normal amou...

Background and Aim: Ovarian torsion is one of the rare causes of emergency surgeries during pregnancy. Heterotopic pregnancy is a rare type of pregnancy characterized by embryo implantation in two different locations. occurence of these two complications at the same time is a very rare condition. In this study, we present a rare case of heterotopic pregnancy accompanied by ovarian torsion. Pat...

The aim of the present study was to understand the interrelationships between stress, hormones and basic ovarian functions in the ovary. For this purpose, we compared the expression of markers of proliferation (PCNA, cyclin B1), of apoptosis (Bax, caspase-3) and secretory activity (release of progesterone, P(4), and insulin-like growth factor, IGF-I) in whole ovarian follicles and granulosa cel...

This study investigated interrelationships between the bovine ovarian cycle and white blood cells and tested the hypothesis that the ovary produces collagen-like materials with leukocyte attractant activity. We examined the in vitro secretion of leukocyte attractant activity by peri-ovulatory ovarian tissues and evaluated the leukocyte attractant potential of some ovarian biochemicals. Fluid fr...