Buildings consume nearly 40% of the annual global energy consumption, with about 70% in hot climate regions. An efficient building design every aspect is a crucial step towards minimizing such consumption. Windows system, including solar shading attachment, plays pivotal role designing sustainable building. At beginning, survey architectural firms was conducted to assess current local practice ...

Telomeric DNA of Tetrahymena thermophila consists of a long stretch of (TTGGGG)n double-stranded repeats with a single-stranded (TTGGGG)2 3' overhang at the end of the chromosome. We have identified and characterized a protein that specifically binds to a synthetic telomeric substrate consisting of duplex DNA and the 3' telomeric repeat overhang. This protein is called TEP (telomere end-binding...

INTRODUCTION Knee pain is a complex problem that can occur after total knee arthroplasty. One cause of knee pain may be due to a retained osteophyte, but it is not clear if the retained osteophyte is sufficient explanation of the pain, as not all patients with retained osteophytes are symptomatic. In fact, the literature shows that excised osteophytes can also recur over a period of time, witho...

PURPOSE To compare the extent of tibial bone covered by the tibial tray in 6 most commonly used total knee arthroplasty designs in order to strike a balance between mediolateral cortical fit and optimal tibial component rotation. METHODS In 74 men and 27 women aged 17 to 60 (mean, 32) years with suspected soft-tissue injuries, their magnetic resonance images of the knee in full extension were...

Poxvirus DNA polymerases play a critical role in promoting virus recombination. To test if vaccinia polymerase (E9L) could mediate this effect by catalyzing the post-synaptic processing of recombinant joint molecules, we prepared substrates bearing a nick, a 3'-unpaired overhang, a 5' overhang, or both 3' and 5' overhangs. The sequence of the 5' overhang was also modified to permit or preclude ...

Since corporate debt tends to be riskier in recessions, transfers from equity holders to debt holders that accompany corporate decisions also tend to concentrate in recessions. Such systematic risk exposures of debt overhang have important implications for corporate investment and financing decisions, and for the ex ante costs of debt overhang. Using a calibrated dynamic capital structure model...

background and aim: an important criterion for success assessment of implant-supported prostheses is marginal fit. vertical and horizontal discrepancy can result in loosening of the prosthetic screw, crestal bone resorption, peri-implantitis and loss of osseointegration. despite careful attention to waxing, investing, and casting, marginal discrepancies are inevitable. the aim of this study was...

This paper highlights the role of the domestic tax system in determining the economic consequences of an external debt overhang. The analysis indicates that fairly strong, and probably unrealistic, assumptions about the domestic tax system are needed to argue that the investment disincentives associated with the debt overhang are large enough to place a country on the wrong side of the debt Laf...

There is considerable controversy over why sluggish economic growth persists across many advanced economies six years after the onset of the financial crisis. Theories include a secular deficiency in aggregate demand, slowing innovation, adverse demographics, lingering policy uncertainty, post-crisis political fractionalisation, debt overhang, insufficient fiscal stimulus, excessive financial r...

ells with shortening telomeres hit two successive barriers: they first stop dividing as they become senescent, and later undergo a cell death process termed crisis. Although crisis may, as suggested by others, be controlled by overall telomere length, and colleagues now blame the onset of senescence on a particular structure at the end of telomeres. The important structure is a single-stranded ...