نتایج جستجو برای: oxazolone induced colitis
تعداد نتایج: 1004569 فیلتر نتایج به سال:
A major DNA oxidation product, 2,2-diamino-4-[(2deoxy-b-D-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), can be generated either directly by oxidation of dG or as a secondary oxidation product with an intermediate of 8-oxo-7,8-dihydro20-deoxyguanosine (8-oxo-dG). Site-specific mutagenesis studies indicate that oxazolone is a strongly mispairing lesion, inducing 10-fold more mutation...
Helminth parasites provoke multicellular immune responses in their hosts that can suppress concomitant disease. The gut lumen-dwelling tapeworm Hymenolepis diminuta, unlike other parasites assessed as helminth therapy, causes no host tissue damage while potently suppressing murine colitis. With the goal of harnessing the immunomodulatory capacity of infection with H. diminuta, we assessed the p...
Regulatory T cells (Tregs) play a fundamental role in regulating the immune system in health and disease. Considerable evidence exists demonstrating that transfer of Tregs can cure colitis and a variety of other inflammatory disorders. However, little is known about the effects of inflammation on resident Tregs. Mice (BALB/c or C57BL/6) treated with an intrarectal instillation of the haptenizin...
Background: Ulcerative colitis is an idiopathic chronic, relapsing inflammation of the colon which is resulted from dysregulation of the mucosal immune system. In Iranian traditional medicine, oleoresin from Pistacia atlantica is used to treat gastrointestinal disorders, including peptic ulcers, dyspepsia and intestinal inflammation. Objective: In this study, we examined the therapeutic and pro...
Objective(s):In the present study, we evaluated immunological and immunomodulatory properties of royal jelly (RJ) in 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. Materials and Methods: Eighteen adult female Wistar albino rats were divided into three groups of six animals each: a control group that received only saline solution, a TNBS-induced colitis group, and a TNBS-co...
Background: Colitis is an inflammatory bowel disease, which is treated effectively with antioxidant and anti-inflammatory drugs. This study evaluated the anti-inflammatory effects of the extracts of Viola odorata and Cassia fistula on the acetic acid-induced colitis in rats. Methods: We determined the total contents of phenols, alkaloids, saponins, and tannins in the plants’ extracts. Further...
ES-62 is the major secreted protein of the rodent filarial nematode Acanthocheilonema viteae. The molecule contains covalently attached phosphorylcholine (PC) residues, which confer anti-inflammatory properties on ES-62, underpinning the idea that drugs based on this active moiety may have therapeutic potential in human diseases associated with aberrant inflammation. Here we demonstrate that tw...
Background and purpose: Ântioxidant and anti-inflammatory compounds can be effective in the treatment of ulcerative colitis. Silymarin has antioxidant and anti-inflammatory properties. The aim of the present study was to evaluate possible useful effects of Silymarin on the reduction of colonic damage and inflammation in experimental acute colitis induced by intracolonic administration of acetic...
OBJECTIVE Eosinophils reside in the colonic mucosa and increase significantly during disease. Although a number of studies have suggested that eosinophils contribute to the pathogenesis of GI inflammation, the expanding scope of eosinophil-mediated activities indicate that they also regulate local immune responses and modulate tissue inflammation. We sought to define the impact of eosinophils t...
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