We have studied the kinetics. biodistribution, and fate of autologous platelets labeled with 111ln-oxine in rabbits. The initial recovery was 75% and mean survival time was 2.8 days when the data were analyzed by the multiple-hit gamma function model. Using a modified geometric mean for correction of attenuation. there was good correlation between the values obtained by in vivo quantification a...

we separated platelets from whole blood and incorporated them into in-ill and te-99m agents. sn-gha, tropolone, oxine (sulphate) and hmpao were used to diffuse radionuclides into the platelets. the effects of time, temperature, ph of incubation media; volume and concentration of ionophore; and volume and activity of ln-l 13m c13 and te-99m on labeling efficiency were studied.