baluchi sheep is considered as the most common breed in iran, constituting about 30% of total sheep population, approximately 15 million heads. this research was designed to study the incidence of mutation in two loci of igf-i (exon 3) and adrb3 (intron) along with their association with body weight traits in baluchi sheep population. following dna extraction from 190 baluchi sheep, two pairs o...

Abstract Background In osteoarthritis (OA), cartilage matrix is lost gradually despite enhanced synthesis by chondrocytes. This paradox may be explained, at least partly, reduced chondrocyte anabolism in degenerated area of OA cartilage. However, to date, it not known why suppressed those areas. Methods Cartilage was obtained from control knees and end-stage macroscopically preserved areas area...

Bladder disease is the tenth most normal malignant growth around world. The analysis and follow-up of patients require exorbitant obtrusive strategies because these costs, bladder keeps on being one costly malignancies. Early determination pivotal in for what it's worth different tumors; this way, non-intrusive biomarkers early conclusion are vital. point investigation was to analyze urinary in...

background:  the aim of this study was to evaluate whether higher serum levels of igf-i in the acute phase of ischemic stroke are associated with less severe strokes and better functional outcome in a period of one year follow up. methods: from october 2014 to august 2015, patients with the diagnosis of acute ischemic stroke admitted to the stroke unit of firoozgar hospital entered this prospec...

Insulin receptor substrate-1 (Irs1) is one of the major substrates for insulin and insulin-like growth factor-1 (IGF-1) tyrosine kinases. Systemic Irs1-deficient mice show retardation, with resistance to IGF-1, although underlying mechanisms remain poorly understood. For this study, we generated brain-specific deletion Irs1 (NIrs1KO mice). The NIrs1KO exhibited lower body weights, shorter bodie...

Sommario La differente modulazione dell’asse GH/IGF-1 da parte degli steroidi sessuali suggerisce una diversa presentazione clinica dell’acromegalia nei due sessi. Tra le donne acromegaliche è stato registrato un maggiore ritardo diagnostico, un’età più avanzata alla diagnosi, rapporto IGF-1/GH basso, maggiori complicanze metaboliche, cefalea, dolore muscolo-scheletrico e comorbidità psichiatri...

The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin factor-1 (IGF-1) genes in oocytes cultured vitro with optimum elevated doses amphiregulin (50 ng 150 ng), neuregulin-1 (25 ng) tumor necrosis factor-α during maturation based on results effects AREG or NRG-1 TNF-α concentration which caused significant effect, ...