Two pools of phosphate-activated glutaminase (PAG) were separated from pig and rat renal mitochondria. The partition of enzyme activity corresponded with that of the immunoreactivity and also with the postembedding immunogold labeling of PAG, which was associated partly with the inner membrane and partly with the matrix. The outer membrane was not labeled. PAG in intact mitochondria showed enzy...

PAG, the phosphoprotein associated with GEMs (glycosphingolipid-enriched microdomains) is a ubiquitously expressed transmembrane adaptor protein that negatively regulates Src-family kinases via the phosphotyrosine-dependent recruitment of Csk to the GEMs. Csk is a cytoplasmic protein tyrosine kinase that phosphorylates the C-terminal inhibitory tyrosine of Src kinases. Upon TCR engagement, PAG ...

This research studies the influence of using SiO2 nano-particles 50nm in a Vapor Compression Refrigeration System (VCRS), along with Poly-alkylene Glycol (PAG) oil and R-134a mixed to create nano-refrigerant. The methodology used this work, were performed three different concentrations (0.1%, 0.3%, 0.5%) 200ml PAG oil. A VCR system was built at mechanical engineering department laboratory Al-Qa...

Our previous studies showed that activation of somatic afferents attenuated the baroreceptor reflex via NK 1 and GABA A receptors within the nucleus of the solitary tract (NTS). The periaqueductal grey matter (PAG) can also depress baroreceptor reflex function and project to the NTS. In the present study, we have tested the possibility that the dorsolateral (dl) PAG projects to the NTS neurons ...

This study was designed to establish possible factors affecting plasma pregnancy-associated glycoprotein (PAG) concentrations during early pregnancy in high producing dairy cows with live fetuses. Blood samples were obtained on days 35, 42, 49, 56 and 63 of gestation from 80 lactating cows in two herds carrying live fetuses. Radioimmunoassay systems were used to determine PAG (RIA-497 and RIA-7...

The midbrain periaqueductal gray (PAG) and the rostral ventromedial medulla (RVM) are important links in a neuronal network that modulates nociceptive transmission. In the RVM, 2 classes of cells have been identified that show changes in activity at the time of the tail-flick response (TF) elicited by noxious heat (Fields et al., 1983a). We now report that neurons in the PAG region also show ch...

pag. 4 INTRODUCTION: pag. 6 Section 1: Stroke  Epidemiology 7  Risk Factors 8  Major recognized mechanisms for ischemic stroke 8  Pathophysiology of ischemic stroke and SAH 8 Section 2: Immune mechanism of stroke pag. 13  The complement system in stroke 18 The lectin pathway 22 Section 3: MBL in health and disease pag. 24  General features of MBL 24  Human MBL: from gene to protein 25 Th...