objectives analysis of ns5a polymorphisms in hcv genotype 1b pre-treatment serum samples from estonian patients and their effect on the treatment response. patients and methods twenty-nine complete ns5a sequences obtained from patients with chronic hcv-1b infection who had received combined therapy with pegifnα-2a/rbv were analyzed and compared with the prototype strain hcv-j. twelve patients a...

conclusions more than one-quarter of treatment-experienced patients with hcv genotype 3 achieved svr after re-treatment with consensus interferon plus ribavirin. objectives we aimed to assess the efficacy and safety of cifn and ribavirin in non-responders and relapsers to pegylated interferon with ribavirin therapy. patients and methods this open-label investigator-initiated study included 44 p...

background chronic hepatitis c virus (hcv) is associated with extra hepatic autoimmune disorders, while peg-ifna-2a/rbv combination therapy may exacerbate these conditions. autoantibodies to cytoplasmic structures, called rod and ring particles (rr), have strong associations with these patients and are identified by hep-2 cells. objectives our purpose was to study the correlation of autoantibod...

itp is an autoimmune blood disorder in which platelet destruction is mediated by anti-platelet antibodies. the mechanisms of anti-platelet antibodies development are still a little known. the rate of some bacterial or viral agents in cause of itp is well known. recently, some study proposed that h pylori infection may be associated with itp and h pylori eradication can improves platelet counts ...

background: the locally advanced head and neck cancer with fixed nodes are incurable and has a short survival. this study aims to evaluate the symptom relief, disease response and acute toxicity after palliative hypofractionated radiotherapy. methods: between december 2010 to june 2011, previously untreated 50 patients who had histopathologically proved of head and neck squamous cell carcinoma ...

background after treatment cessation, a high prevalence of relapse was reported in chronic hepatitis b (chb) patients in china, especially in nucleot(s)ide analogues (nucs)-experienced patients. re-treatment for these patients remains unsolved. objectives this study aims to evaluate the efficacy of pegylated interferon in hbeag positive patients with exposure to antiviral therapy. patients and ...

conclusions examination of the fasting lipid profile has clinical importance in predicting the efficacy of peg-ifn-α-2b plus rbv combination therapy for patients with hcv g1b even after the discovery of the il28 genotype as a potent predictive factor. objectives to re-examine the significance of lipoprotein profiles on virological response to peg-ifn plus rbv combination therapy in patients wit...