UstYa family proteins (DUF3328) are widely and specifically distributed in fungi. They known to be involved the biosynthesis of ribosomally synthesized posttranslationally modified peptides (RiPPs) nonribosomal peptides, possibly catalyze various reactions, including oxidative cyclization chlorination. In this study, we focused on phomopsin A, a fungal RiPP consisting unique nonproteinogenic am...

Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the isomerisation of proline peptide bonds to promote folding and re-folding peptides proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins parvulins. Individual PPIases overexpressed in a number cancers [62], members targetted for immunosuppressant effects.

background and objectives: regarding the importance of finding new antibacterial drugs, screening of plants as a promising resource are now conducted worldwide. in this study, we report the application of a simple previously described method for screening of different plant seeds in order to find the best resources of plant antimicrobial peptides. materials and methods: total water soluble prot...

Scorpions are generally an important source of bioactive components, including toxins and other small peptides as attractive molecules for new drug development. Mesobuthus eupeus, from medically important and widely distributed Buthidae family, is the most abundant species in Iran. Researchers are interesting on the gland of this scorpion due to the complexity of its venom. Here, we have analyz...

Rapid Pd-catalyzed S-arylation with easily accessible 2-[18F]fluoro-5-iodopyridine enables facile preparation of radiolabeled peptides and proteins.

Scorpions are generally an important source of bioactive components, including toxins and other small peptides as attractive molecules for new drug development. Mesobuthus eupeus, from medically important and widely distributed Buthidae family, is the most abundant species in Iran. Researchers are interesting on the gland of this scorpion due to the complexity of its venom. Here, we have analyz...