Aims The X-ray micro-tomography (micro-CT) technique has been used to visualize the microstructure of pharmaceutical granules produced by high shear wet granulation and the dynamic evolution of porosity during granule dissolution. The combination of time-resolved micro-CT imaging with UV/VIS detection of the quantity dissolved made it possible to evaluate the effective diffusion coefficient of ...

Increasingly, poorly soluble drug candidates are entering development, which has made identifying and selecting stable solid forms of an active pharmaceutical ingredient (API) with enhanced in vivo absorption more difficult. While pharmaceutical salts are the most common choice for solid forms, cocrystals are also known to improve “druggability” characteristics such as solubility, dissolution, ...

In this work the electrooxidation half-wave potentials of some Benzoxazines were predicted from their structural molecular descriptors by using quantitative structure-property relationship (QSAR) approaches. The dataset consist the half-wave potential of 40 benzoxazine derivatives which were obtained by DC-polarography. Descriptors which were selected by stepwise multiple selection procedure ar...

The Pharmaceutical Industry witnessed a change after the formation of World Trade Organization (WTO) in 1995 when India, being a signatory member of WTO, adopted Trade-Related Aspects of Intellectual Property Rights (TRIPS) Agreement. Indian pharmaceutical industry, being a highly fragmented one and dominated mostly by a large number of smaller enterprises, was also apprehensive when TRIPS was ...

Polymers are tools used in novel drug delivery system to modify the drug release of pharmaceutical dosage form. Polyox is hydrophilic polymer made of non-ionic homopolymer of ethylene oxide. Polyox is popular for its film forming, binding, lubricating, mucoadhesive, viscosity imparting property in pharmaceuticals. Polyox are available in various grades based on its molecular weight. Lower molec...

Different shades of World Trade Organization (WTO) agreement on trade-related intellectual property rights (TRIPS) are reflected in the Indian pharmaceutical industry, but small and medium-scale pharmaceutical firms are slowly increasing their product innovation, process innovation and research and development (R&D) intensity. Analysis of variance results highlight a significant difference in p...

The inaccessibility of medicines in lowand middle-income countries poses serious human rights and developmental challenges for Governments and international organizations, as well as raising grave ethical and human rights questions about the responsibilities of the research and development-based pharmaceutical industry. In response to this human rights and public-health dilemma, there has been ...