Pharmacogenetics is the study of the role of inheritance in variation to drug response. Drug response phenotypes can vary from adverse drug reactions at one end of the spectrum to equally serious lack of the desired effect of drug therapy at the other. Many of the current important examples of pharmacogenetics involve inherited variation in drug metabolism. Sulfate conjugation catalyzed by cyto...

The hypothesis of each individual being special and different leading to heterogenity of diseases sets the ground for the concept of personalized medicine. Personalized psychiatry follows the principles of personalized medicine. A constituent part of an individually adapted approach towards the psychiatric patient presents itself thorough personalized psychiatry. The development of pharmacogeno...

Pharmacogenetics has revolutionized the way in which drug metabolism was looked upon in the pre-genomic era. Today with the advent of genomics it is possible to genotype an individual. The genetic differences, which determine the disposition of a given drug in an individual, ultimately give differences in drug response. Genotyping and phenotyping tests to predict dose requirement are now increa...

.......................................................................................................................8 REVIEW OF THE LITERATURE...................................................................................10 1 Pharmacogenetics ...........................................................................................................10 2 Drug-Metabolizing Enzymes.............

OBJECTIVE To provide information for community pharmacies considering implementation of a pharmacogenetic testing service. SETTING A single community pharmacy from a regional chain. PRACTICE DESCRIPTION Community pharmacists at the study site routinely provide pharmacy services including medication therapy management, immunizations, point-of-care testing, blood pressure monitoring, and diab...

Electroconvulsive therapy (ECT) has shown apparent efficacy in treatment of patients with depression and other mental illnesses who do not respond to psychotropic medications or need urgent control of their symptoms. Pharmacogenetics contributes to an individual's sensitivity and response to a variety of drugs. Clinical insights into pharmacogenetics of ECT and adjunctive medications not only i...

................................................................................................................................. 8 INTRODUCTION........................................................................................................................... 9 REVIEW OF THE LITERATURE ................................................................................................... 10...

Nothing can put you to sleep faster than a good article on pharmacogenetics. First off it is almost impossible to understand all those words ending with –tide, -ase, etc. that we all learned and immediately forgot when we took our medical boards. Second, it is almost always impossible to figure out the point of the article and how it would actually apply to the actual practice of medicine. Thus...