نتایج جستجو برای: phosphodiesterase inhibitors
تعداد نتایج: 196231 فیلتر نتایج به سال:
OBJECTIVE To examine the role of atrial natriuretic peptide (ANP) and cyclic GMP in the regulation of angiotensin converting enzyme (ACE) in cultured human endothelial cells. METHODS Cultured endothelial cells from human umbilical veins (HUVEC) were treated with ANP (0.3-30 nM), 8-Br-cGMP (1-100 microM), Rp-8-Br-PET-cGMPS (1 microM), or the phosphodiesterase inhibitors, zaprinast (10-100 micr...
Immunoblot and enzyme-activity analyses, using specific immunological probes, indicated that more than 80% of the total low-Km cAMP phosphodiesterase activity present in bovine and human platelets resided in a single phosphodiesterase isozyme. In the presence of protease inhibitors, the platelet enzyme has an apparent subunit size of 110 kDa and appears immunologically and structurally indistin...
Inotropes and vasopressors are frequently required in critically ill patients undergoing major surgery. Several molecules currently available, including catecholamines, phosphodiesterase-3 inhibitors, vasopressin its analogues, calcium sensitizers. We will review current evidence on inotropes use perioperative patients, with focus most recent randomized controlled trials (RCTs). Despite being w...
The role of nitric oxide (NO) in erectile physiology is well documented. NO activates relaxation of corporal cavernosal smooth muscle tissue resulting in increased blood flow into the penis resulting in an erection. At present, pharmacologic treatments for erectile dysfunction, such as the phosphodiesterase-5 inhibitors, potentiate the erectile response generated by NO. However, a new class of ...
A new drug for chronic obstructive pulmonary disease has been recently added as a treatment for certain patients. However, new evidences indicate that there might be a connection with lung cancer. It is known that smoking is a major factor that induces chronic pulmonary disease and smoking is associated with lung cancer. The level of connection between phosphodiesterase (PDE)-4 inhibitors and l...
Introduction Case Physiology of Hemostasis Vasoconstriction Primary Hemostasis Platelet Adhesion Platelet Granule Release Reaction Platelet Aggregation and Consolidation Secondary Hemostasis: The Coagulation Cascade Regulation of Hemostasis Pathogenesis of Thrombosis Endothelial Injury Abnormal Blood Flow Hypercoagulability Pharmacologic Classes and Agents Antiplatelet Agents Cyclooxygenase Inh...
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