objectives: nitric oxide (no) is a signaling molecule that mediates mechanical bone loading. cyclic guanosine 3', 5' monophosphate (cgmp) is a no-induced effector molecule. the aim of this study was to assess the effect of no-cgmp pathway on orthodontic tooth movement (otm) in rats by use of two phosphodiesterase 5 (pde5) inhibitors namely sildenafil and tadalafil as chemical tools. materials a...

       In this study, we investigated the interactive effects of intraperitoneal (i.p.) injections of three different phosphodiesterase inhibitors (PDEIs) on morphine-induced analgesia in mice using tail-flick method. Subcutaneous administration of morphine (1, 3 and 6 mg/kg) caused significant antinociceptive effects in a dose dependent manner. Administration of pentoxifylline (12.5, 25, 50 an...

in this study, we investigated the interactive effects of intraperitoneal (i.p.) injections of three different phosphodiesterase inhibitors (pdeis) on morphine-induced analgesia in mice using tail-flick method. subcutaneous administration of morphine (1, 3 and 6 mg/kg) caused significant antinociceptive effects in a dose dependent manner. administration of pentoxifylline (12.5, 25, 50 and 100 m...

in this paper a general discussion of the available data on the role of prostaglandin (pg) and phosphodiesterase is discussed. functional studies would be a next step to understand the functional meaning of the data described in this paper. the data presented are a basis for further research on selective modulation of the ep1 and ep2 receptor which could be a therapeutic target in functional bl...

the effect of four inhibitors on calmalulin (cum) were studied by a ftuorescence and ultraviolet techniques. four compounds in - ( 6 - aminohexyt) 5-chloro - i - napthalenesulphonamide] (w-7), 1 - [ bis - (4 - chtorophenyt) methyl] - 3 - [2, 4-dichloro - β - ( 2 , 4 - dichlorobenzyloxyl) phenethyt] imidazolium chloride (r24571), trifluoperazine (tfp) , thiodiphenylamide chloride (tdpac) showed ...

Phosphodiesterase 4 (PDE4) has been established as a promising target in asthma andchronic obstructive pulmonary disease. PDE4B subtype selective inhibitors are known toreduce the dose limiting adverse effect associated with non-selective PDE4B inhibitors. Thismakes the development of PDE4B subtype selective inhibitors a desirable research goal. Toachieve this goal, ligand based pharmacophore m...

The inhibitor constants of several inhibitors for cyclic AMP- and cyclic GMP-phosphodiesterase from various organs are compared. The inhibitors were classical theophyline, papaverine, and some of newly developed inhibitors: an imidazolidinone compound, RO20-1724, and two phthalazinol compounds, EG 467 and EG 626. Among the inhibitors tested, papaverine and EG 626 were found to be the most poten...